Human CTLA4 Protein

Product Description

Human CTLA4 Protein
Catalog number: B2012069
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: CTLA-4, CTLA-4 protein, CTLA 4, GSE protein, GRD4 protein, CELIAC3 protein, CTLA4, ICOS protein, IDDM12 protein, CD152 protein, Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor protein, CTLA 4 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Rowshanravan B, Halliday N, Sansom DM. CTLA-4: a moving target in immunotherapy Blood. 2018 Jan 4;131(1):58-67.
2: Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited Annu Rev Immunol. 2005;23:515-48.
3: Byun DJ, Wolchok JD, Rosenberg LM, Girotra M. Cancer immunotherapy – immune checkpoint blockade and associated endocrinopathies Nat Rev Endocrinol. 2017 Apr;13(4):195-207.
4: Chen J, Yang J, Li H, Yang Z, Zhang X, Li X, Wang J, Zhang Y, Chen S, Song M. Single-cell transcriptomics reveal the intratumoral landscape of infiltrated T-cell subpopulations in oral squamous cell carcinoma Mol Oncol. 2021 Apr;15(4):866-886.
5: Lee HT, Lee SH, Heo YS. Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology Molecules. 2019 Mar 26;24(6):1190.
6: Chang HW, Frey G, Liu H, Xing C, Steinman L, Boyle WJ, Short JM. Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2020606118.
7: Tremelimumab Drugs R D. 2010;10(2):123-32.
8: Mantia CM, Buchbinder EI. Immunotherapy Toxicity Hematol Oncol Clin North Am. 2019 Apr;33(2):275-290.
9: Fife BT, Bluestone JA. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways Immunol Rev. 2008 Aug;224:166-82.
10: Parry RV, Chemnitz JM, Frauwirth KA, Lanfranco AR, Braunstein I, Kobayashi SV, Linsley PS, Thompson CB, Riley JL. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms Mol Cell Biol. 2005 Nov;25(21):9543-53.

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