Human CRKL Protein

Description

Human CRKL Protein
Catalog number: B2012030
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Crk-like protein protein,
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Liu Z, Wang Y, Dou C, Xu M, Sun L, Wang L, Yao B, Li Q, Yang W, Tu K, Liu Q. Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma Theranostics. 2018 Sep 9;8(17):4649-4663.
2: Lozic M, Minarik L, Racetin A, Filipovic N, Saraga Babic M, Vukojevic K. CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development Int J Mol Sci. 2021 Aug 25;22(17):9183.
3: Yamauchi T, Kang G, Hiroi N. Heterozygosity of murine Crkl does not recapitulate behavioral dimensions of human 22q11.2 hemizygosity Genes Brain Behav. 2021 Jun;20(5):e12719.
4: Natsume H, Shinmura K, Tao H, Igarashi H, Suzuki M, Nagura K, Goto M, Yamada H, Maeda M, Konno H, Nakamura S, Sugimura H. The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer J Transl Med. 2012 Jul 3;10:97.
5: Fu L, Dong Q, Xie C, Wang Y, Li Q. CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer Tumour Biol. 2015 Feb;36(2):1015-22.
6: Park T. Crk and CrkL as Therapeutic Targets for Cancer Treatment Cells. 2021 Mar 27;10(4):739.
7: Han B, Luan L, Xu Z, Wu B. Clinical significance and biological roles of CRKL in human bladder carcinoma Tumour Biol. 2014 May;35(5):4101-6.
8: Evren S, Ma XZ, Sakac D, Branch DR. SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL Exp Hematol. 2012 Dec;40(12):1055-9.
9: Sattler M, Salgia R. Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells Leukemia. 1998 May;12(5):637-44.
10: Kim JH, Kim K, Kim I, Seong S, Kook H, Kim KK, Koh JT, Kim N. Bifunctional Role of CrkL during Bone Remodeling Int J Mol Sci. 2021 Jun 29;22(13):7007.

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