Human CPSF4 Protein


Catalog Number: B2012020 (100 µg)
Human CPSF4 Protein is a high quality recombinant human CPSF4 protein His tagged and expressed in E.coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Human CPSF4 Protein
Catalog number: B2012020
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: cleavage and polyadenylation specific factor 4 30kDa protein, CPSF30 protein, NAR protein, NEB1 protein, CPSF4, CPSF 4, CPSF-4, CPSF 4 protein, CPSF-4 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Dubois J, Traversier A, Julien T, Padey B, Lina B, Bourdon JC, Marcel V, Boivin G, Rosa-Calatrava M, Terrier O. The Nonstructural NS1 Protein of Influenza Viruses Modulates TP53 Splicing through Host Factor CPSF4 J Virol. 2019 Mar 21;93(7):e02168-18.
2: Chen W, Qin L, Wang S, Li M, Shi D, Tian Y, Wang J, Fu L, Li Z, Guo W, Yu W, Yuan Y, Kang T, Huang W, Deng W. CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas Mol Oncol. 2014 May;8(3):704-16.
3: Tang Z, Yu W, Zhang C, Zhao S, Yu Z, Xiao X, Tang R, Xuan Y, Yang W, Hao J, Xu T, Zhang Q, Huang W, Deng W, Guo W. CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway Mol Oncol. 2016 Feb;10(2):317-29.
4: Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X. Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1533-1543.
5: Wang X, Dong J, Li X, Cheng Z, Zhu Q. CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma Oncogene. 2021 Jun;40(25):4338-4351.
6: Lee K, Zheng Q, Lu Q, Xu F, Qin G, Zhai Q, Hong R, Chen M, Deng W, Wang S. CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4 Signal Transduct Target Ther. 2021 May 19;6(1):184.
7: Yi C, Wang Y, Zhang C, Xuan Y, Zhao S, Liu T, Li W, Liao Y, Feng X, Hao J, Gao Y, Yu W, Chen Y, Zhang C, Guo W, Tang B, Deng W. Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression Cancer Lett. 2016 Oct 10;381(1):1-13.
8: Clark AM, Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML. Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses J Virol. 2017 Aug 10;91(17):e00721-17.
9: Wu J, Miao J, Ding Y, Zhang Y, Huang X, Zhou X, Tang R. MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4 Biochem Cell Biol. 2019 Dec;97(6):722-730.
10: Farhat DC, Bowler MW, Communie G, Pontier D, Belmudes L, Mas C, Corrao C, Couté Y, Bougdour A, Lagrange T, Hakimi MA, Swale C. A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma Elife. 2021 Jul 15;10:e68312.

Products Related to Human CPSF4 Protein can be found at Proteins

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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