Human COMMD1 Protein

Description

Human COMMD1 Protein
Catalog number: B2012002
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 0.5 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: MURR-1, C2orf5 protein, MURR1 protein, COMMD-1 protein, COMMD-1 protein, MURR 1 protein, COMMD1, COMM domain-containing protein 1 protein, COMMD-1, COMMD 1, COMMD 1 protein, COMM protein, COMMD 1 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Riera-Romo M. COMMD1: A Multifunctional Regulatory Protein J Cell Biochem. 2018 Jan;119(1):34-51.
2: Weiskirchen R, Penning LC. COMMD1, a multi-potent intracellular protein involved in copper homeostasis, protein trafficking, inflammation, and cancer J Trace Elem Med Biol. 2021 May;65:126712.
3: Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis Immunity. 2017 Jul 18;47(1):66-79.e5.
4: de Bie P, van de Sluis B, Klomp L, Wijmenga C. The many faces of the copper metabolism protein MURR1/COMMD1 J Hered. 2005;96(7):803-11.
5: Fedoseienko A, Bartuzi P, van de Sluis B. Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis Ann N Y Acad Sci. 2014 May;1314:6-14.
6: Vonk WI, Kakkar V, Bartuzi P, Jaarsma D, Berger R, Hofker MH, Klomp LW, Wijmenga C, Kampinga HH, van de Sluis B. The Copper Metabolism MURR1 domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner PLoS One. 2014 Apr 1;9(4):e92408.
7: van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion J Clin Invest. 2010 Jun;120(6):2119-30.
8: Sarkar B, Roberts EA. The puzzle posed by COMMD1, a newly discovered protein binding Cu(II) Metallomics. 2011 Jan;3(1):20-7.
9: Kudo E, Taura M, Suico MA, Goto H, Kai H, Okada S. Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family Int J Mol Med. 2018 Apr;41(4):2366-2374.
10: Vallespi MG, Mestre B, Marrero MA, Uranga R, Rey D, Lugiollo M, Betancourt M, Silva K, Corrales D, Lamadrid Y, Rodriguez Y, Maceo A, Chaviano PP, Lemos G, Cabrales A, Freyre FM, Santana H, Garay HE, Oliva B, Fernandez JR. A first-in-class, first-in-human, phase I trial of CIGB-552, a synthetic peptide targeting COMMD1 to inhibit the oncogenic activity of NF-κB in patients with advanced solid tumors Int J Cancer. 2021 Sep 15;149(6):1313-1321.

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