Human CIB2 Protein


Catalog Number: B2012409 (25 ug)
Human CIB2 Protein is a high quality Human CIB2 Protein expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Human CIB2 Protein
Catalog number: B2012409
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 ug
Molecular Weight or Concentration: 23.8 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Calcium and integrin-binding family member 2, Kinase-interacting protein 2, KIP 2, CIB2, KIP2
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Dal Cortivo G, Marino V, Iacobucci C, Vallone R, Arlt C, Rehkamp A, Sinz A, Dell’Orco D. Oligomeric state, hydrodynamic properties and target recognition of human Calcium and Integrin Binding protein 2 (CIB2) Sci Rep. 2019 Oct 21;9(1):15058.
2: Sethna S, Scott PA, Giese APJ, Duncan T, Jian X, Riazuddin S, Randazzo PA, Redmond TM, Bernstein SL, Riazuddin S, Ahmed ZM. CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function Nat Commun. 2021 Jun 23;12(1):3906.
3: Liang X, Qiu X, Dionne G, Cunningham CL, Pucak ML, Peng G, Kim YH, Lauer A, Shapiro L, Müller U. CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells Neuron. 2021 Jul 7;109(13):2131-2149.e15.
4: Koenekoop RK, Arriaga MA, Trzupek KM, Lentz JJ. Usher Syndrome Type I 1999 Dec 10 [updated 2020 Oct 8]. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews(®) [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.
5: Jacoszek A, Pollak A, Płoski R, Ołdak M. Advances in genetic hearing loss: CIB2 gene Eur Arch Otorhinolaryngol. 2017 Apr;274(4):1791-1795.
6: Riazuddin S, Belyantseva IA, Giese AP, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZM. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48 Nat Genet. 2012 Nov;44(11):1265-71.
7: Dal Cortivo G, Dell’Orco D. Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides Int J Mol Sci. 2022 Mar 24;23(7):3552.
8: Patel K, Giese AP, Grossheim JM, Hegde RS, Delio M, Samanich J, Riazuddin S, Frolenkov GI, Cai J, Ahmed ZM, Morrow BE. A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family PLoS One. 2015 Oct 1;10(10):e0133082.
9: Wang Y, Li J, Yao X, Li W, Du H, Tang M, Xiong W, Chai R, Xu Z. Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice Front Mol Neurosci. 2017 Dec 4;10:401.
10: Huang H, Bogstie JN, Vogel HJ. Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences Biochem Cell Biol. 2012 Oct;90(5):646-56.

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