Human CHAC2 Protein

Description

Human CHAC2 Protein
Catalog number: B2011934
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 500 µg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Cation transport regulator-like protein 2 protein, ChaC protein, cation transport regulator homolog 2 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kaur A, Gautam R, Srivastava R, Chandel A, Kumar A, Karthikeyan S, Bachhawat AK. ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione J Biol Chem. 2017 Jan 13;292(2):638-651.
2: Nguyen YTK, Park JS, Jang JY, Kim KR, Vo TTL, Kim KW, Han BW. Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism Biomolecules. 2019 Dec 24;10(1):31.
3: Wang CK, Yang SC, Hsu SC, Chang FP, Lin YT, Chen SF, Cheng CL, Hsiao M, Lu FL, Lu J. CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells Free Radic Biol Med. 2017 Dec;113:439-451.
4: Liu S, Fei W, Shi Q, Li Q, Kuang Y, Wang C, He C, Hu X. CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response Cell Death Dis. 2017 Aug 24;8(8):e3009.
5: Bachhawat AK, Kaur A. Glutathione Degradation Antioxid Redox Signal. 2017 Nov 20;27(15):1200-1216.
6: Liu G, Zeng X, Wu B, Zhao J, Pan Y. RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with radiotherapy response of nasopharyngeal carcinoma and prognosis of head and neck cancer Cancer Biol Ther. 2020;21(2):139-146.
7: Zhai X, Dai T, Chi Z, Zhao Z, Wu G, Yang S, Dong D. Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation Environ Toxicol. 2022 Jun;37(6):1332-1342.
8: Wang C, Zheng W, Yao D, Chen Q, Zhu L, Zhang J, Pan Y, Zhang J, Shao C. Upregulation of DNA Metabolism-Related Genes Contributes to Radioresistance of Glioblastoma Hum Gene Ther Clin Dev. 2019 Jun;30(2):74-87.
9: Quan K, Cao Z, Xu Q, Zhu M, Liu X, Dai M. A web-based calculator for predicting the prognosis of patients with sarcoma on the basis of antioxidant gene signatures Aging (Albany NY). 2022 Feb 10;14(3):1407-1428.
10: Gopalakrishnan K, Kumarasamy S, Mell B, Joe B. Genome-wide identification of long noncoding RNAs in rat models of cardiovascular and renal disease Hypertension. 2015 Jan;65(1):200-10.

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