Human CCM2 Protein

Product Description

Human CCM2 Protein
Catalog number: B2011850
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 500 µg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Malcavernin isoform 4 protein, CCM 2 protein, CCM-2 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Peyre M, Miyagishima D, Bielle F, Chapon F, Sierant M, Venot Q, Lerond J, Marijon P, Abi-Jaoude S, Le Van T, Labreche K, Houlston R, Faisant M, Clémenceau S, Boch AL, Nouet A, Carpentier A, Boetto J, Louvi A, Kalamarides M. Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations N Engl J Med. 2021 Sep 9;385(11):996-1004.
2: Jiang X, Padarti A, Qu Y, Sheng S, Abou-Fadel J, Badr A, Zhang J. Alternatively spliced isoforms reveal a novel type of PTB domain in CCM2 protein Sci Rep. 2019 Nov 1;9(1):15808.
3: Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling Nature. 2016 Apr 7;532(7597):122-6.
4: Stahl S, Gaetzner S, Voss K, Brackertz B, Schleider E, Sürücü O, Kunze E, Netzer C, Korenke C, Finckh U, Habek M, Poljakovic Z, Elbracht M, Rudnik-Schöneborn S, Bertalanffy H, Sure U, Felbor U. Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex Hum Mutat. 2008 May;29(5):709-17.
5: Tanriover G, Sozen B, Gunel M, Demir N. CCM2 expression during prenatal development and adult human neocortex Int J Dev Neurosci. 2011 Aug;29(5):509-14.
6: Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation J Cell Biol. 2015 Mar 30;208(7):987-1001.
7: Costa B, Kean MJ, Ast V, Knight JD, Mett A, Levy Z, Ceccarelli DF, Badillo BG, Eils R, König R, Gingras AC, Fainzilber M. STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin J Biol Chem. 2012 Aug 24;287(35):29285-9.
8: Harel L, Costa B, Fainzilber M. On the death Trk Dev Neurobiol. 2010 Apr;70(5):298-303.
9: Boulday G, Blécon A, Petit N, Chareyre F, Garcia LA, Niwa-Kawakita M, Giovannini M, Tournier-Lasserve E. Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations Dis Model Mech. 2009 Mar-Apr;2(3-4):168-77.
10: Zawistowski JS, Stalheim L, Uhlik MT, Abell AN, Ancrile BB, Johnson GL, Marchuk DA. CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis Hum Mol Genet. 2005 Sep 1;14(17):2521-31.

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