Human BECN1 Protein

Description

Human BECN1 Protein
Catalog number: B2011607
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 µg
Molecular Weight or Concentration: 0.25 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: VPS30 protein, BECN-1, BECN1, BECN-1 protein, beclin 1 protein, beclin1 protein, BECN 1, BECN 1 protein, ATG6 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, Xu F, Hu F, Chen L, Luo X, Feng Y, Huang S, Hu J, Wang G. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation Nat Commun. 2021 Jun 15;12(1):3651.
2: Park E, Chung SW. ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation Cell Death Dis. 2019 Oct 28;10(11):822.
3: Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D. AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System X(c)(-) Activity Curr Biol. 2018 Aug 6;28(15):2388-2399.e5.
4: Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis Cell Death Differ. 2011 Apr;18(4):571-80.
5: Li X, Yang KB, Chen W, Mai J, Wu XQ, Sun T, Wu RY, Jiao L, Li DD, Ji J, Zhang HL, Yu Y, Chen YH, Feng GK, Deng R, Li JD, Zhu XF. CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression Autophagy. 2021 Dec;17(12):4323-4340.
6: Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mösbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Müller-Myhsok B, Drosten C, Müller MA, Rein T. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection Nat Commun. 2019 Dec 18;10(1):5770.
7: Han T, Guo M, Gan M, Yu B, Tian X, Wang JB. TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 Autophagy. 2018;14(12):2035-2048.
8: Liu K, Guo C, Lao Y, Yang J, Chen F, Zhao Y, Yang Y, Yang J, Yi J. A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3 Autophagy. 2020 Jun;16(6):975-990.
9: Kuramoto K, Kim YJ, Hong JH, He C. The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding Cell Rep. 2021 May 25;35(8):109184.
10: Zhou C, Qian X, Hu M, Zhang R, Liu N, Huang Y, Yang J, Zhang J, Bai H, Yang Y, Wang Y, Ali D, Michalak M, Chen XZ, Tang J. STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I Autophagy. 2020 Oct;16(10):1786-1806.

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