Human AKR1C1 Protein (Highly Pure)

Product Description

Human AKR1C1 Protein (Highly Pure)
Catalog number: B2011564
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 0.5 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: AKRC 1, Aldo keto reductase family 1 member C1 protein, AKRC-1, DDH protein, Chlordecone reductase homolog protein, Dihydrodiol dehydrogenase 1 protein, Chlordecone reductase homolog HAKRC protein, , DD1/DD2 protein, AK1C1 protein, C9 protein, 2 diol dehydrogenase protein, AKRC 1 protein, MBAB protein, Trans-1 protein, HAKRC protein, DDH1 protein, 20 alpha hydroxysteroid dehydrogenase protein, HBAB protein, member C1 20 alpha (3 alpha) hydroxysteroid dehydrogenase protein, 20-alpha-HSD protein, AKRC-1 protein, 2 dihydrobenzene 1 protein, DD1 protein, 2ALPHAHSD protein, Aldo-keto reductase family 1 protein, H37 protein, High affinity hepatic bile acid-binding protein , Hepatic dihydrodiol dehydrogenase protein, AKR1C1, Dihydrodiol dehydrogenase 1/2 protein, Type II 3 alpha hydroxysteroid dehydrogenase protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Penning TM. The aldo-keto reductases (AKRs): Overview Chem Biol Interact. 2015 Jun 5;234:236-46.
3: Wohlhieter CA, Richards AL, Uddin F, Hulton CH, Quintanal-Villalonga À, Martin A, de Stanchina E, Bhanot U, Asher M, Shah NS, Hayatt O, Buonocore DJ, Rekhtman N, Shen R, Arbour KC, Donoghue M, Poirier JT, Sen T, Rudin CM. Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer Cell Rep. 2020 Dec 1;33(9):108444.
4: El-Kabbani O, Dhagat U, Hara A. Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1) J Steroid Biochem Mol Biol. 2011 May;125(1-2):105-11.
5: Li K, Ding S, Chen K, Qin D, Qu J, Wang S, Sheng Y, Zou C, Chen L, Tang H. Hepatitis B Virus X Protein Up-Regulates AKR1C1 Expression Through Nuclear Factor-Y in Human Hepatocarcinoma Cells Hepat Mon. 2013 May 27;13(5):e8792.
6: Chu X, He S, Liu Y, Liu Y, Feng F, Guo Q, Zhao L, Sun H. Overview of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1): Functions, regulation, and structural insights of inhibitors Chem Biol Interact. 2022 Jan 5;351:109746.
7: Gagliardi M, Cotella D, Santoro C, Corà D, Barlev NA, Piacentini M, Corazzari M. Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis Cell Death Dis. 2019 Nov 28;10(12):902.
8: Beranič N, Gobec S, Rižner TL. Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3 Chem Biol Interact. 2011 May 30;191(1-3):227-33.
9: Gao Y, Xu D, Li H, Xu J, Pan Y, Liao X, Qian J, Hu Y, Yu G. Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling Front Oncol. 2021 May 28;11:677678.
10: Wang X, Yang B, Li Y, Luo J, Wang Y. AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway Mol Med Rep. 2021 Dec;24(6):833.

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