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Human 5-Hydroxytryptamine 2B Receptor

Original price was: $18,795.00.Current price is: $9,395.00.

Catalog Number: B2016513 (25 µg)
Human 5-Hydroxytryptamine 2B Receptor is a high quality protein that is encoded by the HTR2B gene in humans. It is a subtype of the serotonin receptor that is involved in various physiological processes, including neurotransmission, mood regulation, and cardiovascular function. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2016513 Categories: , Tag:

Product Description

Human 5-Hydroxytryptamine 2B Receptor
Catalog number: B2016513
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 µg
Molecular Weight or Concentration: N/A
Supplied as: N/A
Applications: a molecular tool for various biochemical applications
Storage: N/A
Keywords: 5-HT-2B
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Reid TE, Kumar K, Wang XS. Predictive in silico studies of human 5-hydroxytryptamine receptor subtype 2B (5-HT2B) and valvular heart disease Curr Top Med Chem. 2013;13(11):1353-62.
2: McCorvy JD, Roth BL. Structure and function of serotonin G protein-coupled receptors Pharmacol Ther. 2015 Jun;150:129-42.
3: David DJ, Gardier AM. [The pharmacological basis of the serotonin system: Application to antidepressant response] Encephale. 2016 Jun;42(3):255-63.
4: Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat J Pharmacol Exp Ther. 2002 Oct;303(1):179-87.
5: Bennet H, Mollet IG, Balhuizen A, Medina A, Nagorny C, Bagge A, Fadista J, Ottosson-Laakso E, Vikman P, Dekker-Nitert M, Eliasson L, Wierup N, Artner I, Fex M. Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans Diabetologia. 2016 Apr;59(4):744-54.
6: Bender AM, Parr LC, Livingston WB, Lindsley CW, Merryman WD. 2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery J Med Chem. 2023 Aug 24;66(16):11027-11039.
7: Löfdahl A, Tornling G, Wigén J, Larsson-Callerfelt AK, Wenglén C, Westergren-Thorsson G. Pathological Insight into 5-HT(2B) Receptor Activation in Fibrosing Interstitial Lung Diseases Int J Mol Sci. 2020 Dec 28;22(1):225.
8: Wenglén C, Demirel I, Eremo AG, Grenegård M, Paramel GV. Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells Eur J Pharmacol. 2023 Apr 5;944:175570.
9: Peng L, Huang J. Astrocytic 5-HT(2B) receptor as in vitro and in vivo target of SSRIs Recent Pat CNS Drug Discov. 2012 Dec;7(3):243-53.
10: McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL. Structural determinants of 5-HT(2B) receptor activation and biased agonism Nat Struct Mol Biol. 2018 Sep;25(9):787-796.

Products Related to Human 5-Hydroxytryptamine 2B Receptor can be found at Proteins

Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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