Hrk BH3 Domain Peptide


Catalog Number: B2012840 (500 ug)
Hrk BH3 Domain Peptide is a high quality synthetic Hrk BH3 domain peptide. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Hrk BH3 Domain Peptide
Catalog number: B2012840
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 ug
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, Neuronal death protein DP5, HRK, BID3
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, Kang D, Tashiro F, Gotoh Y, Kuchino Y, Kitanaka C. Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32 Cell Death Differ. 2004 Jul;11(7):771-81.
2: Bernabeu A, Guillén J, Pérez-Berná AJ, Moreno MR, Villalaín J. Structure of the C-terminal domain of the pro-apoptotic protein Hrk and its interaction with model membranes Biochim Biophys Acta. 2007 Jun;1768(6):1659-70.
3: Pinto M, Perez JJ, Rubio-Martinez J. Molecular dynamics study of peptide segments of the BH3 domain of the proapoptotic proteins Bak, Bax, Bid and Hrk bound to the Bcl-xL and Bcl-2 proteins J Comput Aided Mol Des. 2004 Jan;18(1):13-22.
4: Lutz RJ. Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins Biochem Soc Trans. 2000 Feb;28(2):51-6.
5: Suraweera CD, Burton DR, Hinds MG, Kvansakul M. Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax FEBS Lett. 2020 Jun;594(12):2016-2026.
6: Ye K, Meng WX, Sun H, Wu B, Chen M, Pang YP, Gao J, Wang H, Wang J, Kaufmann SH, Dai H. Characterization of an alternative BAK-binding site for BH3 peptides Nat Commun. 2020 Jul 3;11(1):3301.
7: Santiveri CM, Sborgi L, de Alba E. Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members J Mol Recognit. 2012 Dec;25(12):665-73.
8: Inohara N, Ding L, Chen S, Núñez G. harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L) EMBO J. 1997 Apr 1;16(7):1686-94.
9: Hockings C, Anwari K, Ninnis RL, Brouwer J, O’Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM. Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax Cell Death Dis. 2015 Apr 23;6(4):e1735.
10: Choi YB, Sandford G, Nicholas J. Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry PLoS Pathog. 2012;8(6):e1002748.

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