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Histone Acetyltransferase Inhibitor II

Original price was: $1,595.00.Current price is: $795.00.

Catalog Number: B2013343 (5 mg)
Histone Acetyltransferase Inhibitor II is a high quality Histone Acetyltransferase Inhibitor II. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

Histone Acetyltransferase Inhibitor II
Catalog number: B2013343
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 464.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: Histone Acetyltransferase Inhibitor II, 2,6- bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Li B, Samanta A, Song X, Iacono KT, Bembas K, Tao R, Basu S, Riley JL, Hancock WW, Shen Y, Saouaf SJ, Greene MI. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4571-6.
2: Li Q, Li Z, Lou A, Wang Z, Zhang D, Shen QW. Histone acetyltransferase inhibitors antagonize AMP-activated protein kinase in postmortem glycolysis Asian-Australas J Anim Sci. 2017 Jun;30(6):857-864.
3: Alsamri H, Hasasna HE, Baby B, Alneyadi A, Dhaheri YA, Ayoub MA, Eid AH, Vijayan R, Iratni R. Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer Front Oncol. 2021 May 13;11:664403.
4: Wanczyk M, Roszczenko K, Marcinkiewicz K, Bojarczuk K, Kowara M, Winiarska M. HDACi–going through the mechanisms Front Biosci (Landmark Ed). 2011 Jan 1;16(1):340-59.
5: Tasneem S, Alam MM, Amir M, Akhter M, Parvez S, Verma G, Nainwal LM, Equbal A, Anwer T, Shaquiquzzaman M. Heterocyclic Moieties as HDAC Inhibitors: Role in Cancer Therapeutics Mini Rev Med Chem. 2022;22(12):1648-1706.
6: Han Y, Nie J, Wang DW, Ni L. Mechanism of histone deacetylases in cardiac hypertrophy and its therapeutic inhibitors Front Cardiovasc Med. 2022 Jul 26;9:931475.
7: Zhang BL, Guo TW, Gao LL, Ji GQ, Gu XH, Shao YQ, Yao RQ, Gao DS. Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II Oncotarget. 2017 Jul 11;8(28):45105-45116.
8: Adcock IM. Glucocorticoid-regulated transcription factors Pulm Pharmacol Ther. 2001;14(3):211-9.
9: Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N, Nakano T, Kohno T. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe Radiother Oncol. 2014 May;111(2):222-7.
10: Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM. Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells Mol Pharmacol. 2008 May;73(5):1454-64.

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Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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