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High Sensitivity beta-Galactosidase Substrate (HSPG)

$295.00

Catalog Number: B2010525 (100 mg)
High Sensitivity Beta-Galactosidase Substrate (HSPG) is a highly pure ultra high extinction coefficient substrate for beta-galactosidase enzymatic reagents that surpasses all traditional substrates such as ONPG and CPRG. This product has been used as substrate in the development of ultra-sensitive beta-galactosidase-based assays. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2010525 Categories: ,

Description

High Sensitivity beta-Galactosidase Substrate (HSPG)
Catalog number: B2010525
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: substrate in the development of ultra-sensitive beta-galactosidase-based assays
Storage: −20°C
Keywords: b-gal substrate, CEDIA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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senescence: the senescence-associated beta-galactosidase assay. Methods Mol
Biol. 2007;371:21-31.

2: Smale ST. Beta-galactosidase assay. Cold Spring Harb Protoc. 2010
May;2010(5):pdb.prot5423.

3: Fuhrmann-Stroissnigg H, Santiago FE, Grassi D, Ling Y, Niedernhofer LJ,
Robbins PD. SA-β-Galactosidase-Based Screening Assay for the Identification of
Senotherapeutic Drugs. J Vis Exp. 2019 Jun 28;(148).

4: Lu G, Yi J, Gubas A, Wang YT, Wu Y, Ren Y, Wu M, Shi Y, Ouyang C, Tan HWS,
Wang T, Wang L, Yang ND, Deng S, Xia D, Chen RH, Tooze SA, Shen HM. Suppression
of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2
polyubiquitination and proteasomal degradation. Autophagy. 2019
Nov;15(11):1917-1934.

5: Ghéczy N, Küchler A, Walde P. Proteinase K activity determination with
β-galactosidase as sensitive macromolecular substrate. Anal Biochem. 2016 Nov
15;513:54-60.

6: Ullah K, Chen S, Lu J, Wang X, Liu Q, Zhang Y, Long Y, Hu Z, Xu G. The E3
ubiquitin ligase STUB1 attenuates cell senescence by promoting the
ubiquitination and degradation of the core circadian regulator BMAL1. J Biol
Chem. 2020 Apr 3;295(14):4696-4708.

7: Srinivas S, Watanabe T, Lin CS, William CM, Tanabe Y, Jessell TM, Costantini
F. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the
ROSA26 locus. BMC Dev Biol. 2001;1:4.

8: Tian S, Zhang Z, Chen J, Du M, Li Z, Yang H, Ji X, He Z. Digital analysis
with droplet-based microfluidic for the ultrasensitive detection of β-gal and
AFP. Talanta. 2018 Aug 15;186:24-28.

9: Gong H, Zhang B, Little G, Kovar J, Chen H, Xie W, Schutz-Geschwender A,
Olive DM. beta-Galactosidase activity assay using far-red-shifted fluorescent
substrate DDAOG. Anal Biochem. 2009 Mar 1;386(1):59-64.
10: Zhang H. (1-(2-(β-Galactopyranosyloxy)propyl)-4,7,10-tris(carboxymethyl)-1,4
,7,10-tetraazacyclododecane) gadolinium(III). 2008 Jan 14 [updated 2008 Feb 20].
In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda
(MD): National Center for Biotechnology Information (US); 2004–2013.

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