Sale!

Granzyme B Inhibitor II

Original price was: $1,195.00.Current price is: $595.00.

Catalog Number: B2013840 (1 mg)
Granzyme B Inhibitor II is a high quality reversible inhibitor of granzyme B and caspase-8. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

In stock

SKU: B2013840 Categories: , Tag:

Product Description

Granzyme B Inhibitor II
Catalog number: B2013840
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration:
502.52
Supplied as: Lyophilized Solid
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Iizuka A, Nonomura C, Ashizawa T, Kondou R, Ohshima K, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Maruyama K, Yamaguchi K, Akiyama Y. A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer Clin Cancer Res. 2019 May 1;25(9):2925-2934.
2: Zhu S, Ma AH, Zhu Z, Adib E, Rao T, Li N, Ni K, Chittepu VCSR, Prabhala R, Garisto Risco J, Kwiatkowski D, Mouw K, Sonpavde G, Cheng F, Pan CX. Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer J Immunother Cancer. 2021 Nov;9(11):e002917.
3: Yu W, Ye F, Yuan X, Ma Y, Mao C, Li X, Li J, Dai C, Qian F, Li J, Fan X, Zhou Y, Wang D, Guo Z, An H, Zhang M, Chen D, Xia S. A phase I/II clinical trial on the efficacy and safety of NKT cells combined with gefitinib for advanced EGFR-mutated non-small-cell lung cancer BMC Cancer. 2021 Jul 31;21(1):877.
4: Bouwman AC, van Daalen KR, Crnko S, Ten Broeke T, Bovenschen N. Intracellular and Extracellular Roles of Granzyme K Front Immunol. 2021 May 4;12:677707.
5: Parra ER, Villalobos P, Behrens C, Jiang M, Pataer A, Swisher SG, William WN Jr, Zhang J, Lee J, Cascone T, Heymach JV, Forget MA, Haymaker C, Bernatchez C, Kalhor N, Weissferdt A, Moran C, Zhang J, Vaporciyan A, Gibbons DL, Sepesi B, Wistuba II. Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches J Immunother Cancer. 2018 Jun 6;6(1):48.
6: Azzi J, Skartsis N, Mounayar M, Magee CN, Batal I, Ting C, Moore R, Riella LV, Ohori S, Abdoli R, Smith B, Fiorina P, Heathcote D, Bakhos T, Ashton-Rickardt PG, Abdi R. Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells J Immunol. 2013 Sep 1;191(5):2319-27.
7: Muthukumar T, Ding R, Dadhania D, Medeiros M, Li B, Sharma VK, Hartono C, Serur D, Seshan SV, Volk HD, Reinke P, Kapur S, Suthanthiran M. Serine proteinase inhibitor-9, an endogenous blocker of granzyme B/perforin lytic pathway, is hyperexpressed during acute rejection of renal allografts Transplantation. 2003 May 15;75(9):1565-70.
8: Froelich CJ, Zhang X, Turbov J, Hudig D, Winkler U, Hanna WL. Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes J Immunol. 1993 Dec 15;151(12):7161-71.
9: Motyka B, Korbutt G, Pinkoski MJ, Heibein JA, Caputo A, Hobman M, Barry M, Shostak I, Sawchuk T, Holmes CF, Gauldie J, Bleackley RC. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis Cell. 2000 Oct 27;103(3):491-500.
10: Bossard C, Belhadj K, Reyes F, Martin-Garcia N, Berger F, Kummer JA, Brire J, Baglin AC, Cheze S, Bosq J, Ribrag V, Gisselbrecht C, Mounier N, Gaulard P. Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d’Etude des Lymphomes de l’Adulte (GELA) trials Blood. 2007 Mar 1;109(5):2183-9.

Products Related to Granzyme B Inhibitor II can be found at Chemicals

Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

Several ways to order Molecular Depot products:

1- Order online using our website’s automated shopping cart and checkout system (available 24/7).

2- Order by email: info@moleculardepot.com (we accept electronic PO, available 24/7).

3- Order by Fax: 1-858-437-9884 (available 24/7).

4- Order by Phone: 1-858-900-3210 (available 24/7).

5- Order by Text/SMS: 1-858-900-3210 (available 24/7).