Granulocyte Chemotactic Protein-2/CXCL6 (Human)

Description

Granulocyte Chemotactic Protein-2/CXCL6 (Human)
Catalog number: B2010271
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized powder
Appearance: Powder
Applications: highly pure Granulocyte Chemotactic Protein-2/CXCL6, expressed in CHO cells. This protein acts as a chemokine produced by macrophages as well as epithelial and mesenchymal cells during an inflammation reaction.
Storage: -20C
Keywords: rHuGCP-2/CXCL6; CKA-3; SCYB6
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through0.22 um.

References:
1: Van Damme J, Wuyts A, Froyen G, Van Coillie E, Struyf S, Billiau A, Proost P,
Wang JM, Opdenakker G. Granulocyte chemotactic protein-2 and related CXC
chemokines: from gene regulation to receptor usage. J Leukoc Biol. 1997
Nov;62(5):563-9.

2: Kebschull M, Demmer R, Behle JH, Pollreisz A, Heidemann J, Belusko PB,
Celenti R, Pavlidis P, Papapanou PN. Granulocyte chemotactic protein 2
(gcp-2/cxcl6) complements interleukin-8 in periodontal disease. J Periodontal
Res. 2009 Aug;44(4):465-71.

3: Wuyts A, D’Haese A, Cremers V, Menten P, Lenaerts JP, De Loof A, Heremans H,
Proost P, Van Damme J. NH2- and COOH-terminal truncations of murine granulocyte
chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic
potency. J Immunol. 1999 Dec 1;163(11):6155-63.

4: D’Haese A, Wuyts A, Dillen C, Dubois B, Billiau A, Heremans H, Van Damme J,
Arnold B, Opdenakker G. In vivo neutrophil recruitment by granulocyte
chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse. J
Interferon Cytokine Res. 2000 Jul;20(7):667-74.

5: Wolf M, Delgado MB, Jones SA, Dewald B, Clark-Lewis I, Baggiolini M.
Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2.
Eur J Immunol. 1998 Jan;28(1):164-70.

6: Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A,
Oppenheim JJ, Proost P, Van Damme J. Characterization of synthetic human
granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2
and in vivo inflammatory properties. Biochemistry. 1997 Mar 4;36(9):2716-23.

7: Zhu YM, Bagstaff SM, Woll PJ. Production and upregulation of granulocyte
chemotactic protein-2/CXCL6 by IL-1beta and hypoxia in small cell lung cancer.
Br J Cancer. 2006 Jun 19;94(12):1936-41.

8: Singh UP, Singh S, Boyaka PN, McGhee JR, Lillard JW Jr. Granulocyte
chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta
interactions. J Leukoc Biol. 2004 Dec;76(6):1240-7.

9: Wuyts A, Haelens A, Proost P, Lenaerts JP, Conings R, Opdenakker G, Van Damme
J. Identification of mouse granulocyte chemotactic protein-2 from fibroblasts
and epithelial cells. Functional comparison with natural KC and macrophage
inflammatory protein-2. J Immunol. 1996 Aug 15;157(4):1736-43.
10: Linge HM, Collin M, Nordenfelt P, Mörgelin M, Malmsten M, Egesten A. The
human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses
membrane-disrupting properties and is antibacterial. Antimicrob Agents
Chemother. 2008 Jul;52(7):2599-607.

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