Glutamate Dehydrogenase (Bovine Liver)

Product Description

Glutamate Dehydrogenase (Bovine Liver)
Catalog number: B2010234
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 20 mg
pH: na
Supplied as: Ready-to-use
Appearance: Lyophilized Powder
Applications: high purity (95%), high specific activity (19U/mg) freeze-dried powder of Glutamate Dehydrogenase (GLDH), a mitochondrial enzyme that catalyzes the oxidative deamination of glutamate into α-ketoglutarate.
Storage: -20°C
Keywords: GLDH, GDH, Glutamate Dehydrogenase
Grade: Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered on a 0.22 um.

References:
1: Smith HQ, Li C, Stanley CA, Smith TJ. Glutamate Dehydrogenase, a Complex
Enzyme at a Crucial Metabolic Branch Point. Neurochem Res. 2019
Jan;44(1):117-132.

2: Craze ML, El-Ansari R, Aleskandarany MA, Cheng KW, Alfarsi L, Masisi B, Diez-
Rodriguez M, Nolan CC, Ellis IO, Rakha EA, Green AR. Glutamate dehydrogenase
(GLUD1) expression in breast cancer. Breast Cancer Res Treat. 2019
Feb;174(1):79-91.

3: Jin Y, Li D, Lu S, Zhao H, Chen Z, Hou W, Ruan BH. Ebselen Reversibly
Inhibits Human Glutamate_Dehydrogenase at the Catalytic Site. Assay Drug Dev
Technol. 2018 Feb/Mar;16(2):115-122.

4: Li M, Li C, Allen A, Stanley CA, Smith TJ. Glutamate dehydrogenase:
structure, allosteric regulation, and role in insulin homeostasis. Neurochem
Res. 2014;39(3):433-45.

5: Plaitakis A, Zaganas I, Spanaki C. Deregulation of glutamate_dehydrogenase in
human neurologic disorders. J Neurosci Res. 2013 Aug;91(8):1007-17.

6: Spanaki C, Plaitakis A. The role of glutamate_dehydrogenase in mammalian
ammonia metabolism. Neurotox Res. 2012 Jan;21(1):117-27.

7: Hull J, Usmari Moraes M, Brookes E, Love S, Conway ME. Distribution of the
branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate
dehydrogenase in the human brain and their role in neuro-metabolism. Neurochem
Int. 2018 Jan;112:49-58.

8: Shashidharan P, Plaitakis A. The discovery of human of GLUD2 glutamate
dehydrogenase and its implications for cell function in health and disease.
Neurochem Res. 2014;39(3):460-70.

9: Tomita T, Yin L, Nakamura S, Kosono S, Kuzuyama T, Nishiyama M. Crystal
structure of the 2-iminoglutarate-bound complex of glutamate_dehydrogenase from
Corynebacterium glutamicum. FEBS Lett. 2017 Jun;591(11):1611-1622.

10: Smith TJ, Stanley CA. Untangling the glutamate_dehydrogenase allosteric
nightmare. Trends Biochem Sci. 2008 Nov;33(11):557-64.

11: Nassar OM, Wong KY, Lynch GC, Smith TJ, Pettitt BM. Allosteric
discrimination at the NADH/ADP regulatory site of glutamate_dehydrogenase.
Protein Sci. 2019 Dec;28(12):2080-2088.

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