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Fms-related Tyrosine Kinase 3 Ligand

$495.00

Catalog Number: B2010329 (10 ug)
Fms-related Tyrosine Kinase 3 Ligand is a high quality research product used as highly pure Fms-related Tyrosine Kinase 3 Ligand expressed in CHO. This protein acts as a cytokine that promotes the generation and differentiation of hematopoietic stem cells and their progenitor cells. Custom bulk orders of this product are available upon request.

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SKU: B2010329 Categories: ,

Description

Fms-related Tyrosine Kinase 3 Ligand
Catalog number: B2010329
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Fms-related Tyrosine Kinase 3 Ligand expressed in CHO. This protein acts as a cytokine that promotes the generation and differentiation of hematopoietic stem cells and their progenitor cells.
Storage: -20C
Keywords: rHuFlt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ling L, Tang X, Huang X, Li J, Wang H, Chen Z. AAV-Vectored Fms-Related
Tyrosine Kinase 3 Ligand Inhibits CD34+ Progenitor Cell Engraftment
in Humanized Mice. J Neuroimmune Pharmacol. 2018 Dec;13(4):541-550.

2: Posod A, Wegleiter K, Neubauer V, Urbanek M, Huber E, Kiechl-Kohlendorfer U,
Keller M, Griesmaier E. Short-, Mid-, and Long-Term Effect of Granulocyte
Colony-Stimulating Factor/Stem Cell Factor and Fms-Related Tyrosine Kinase 3
Ligand Evaluated in an In Vivo Model of Hypoxic-Hyperoxic Ischemic Neonatal
Brain Injury. Biomed Res Int. 2019 Mar 13;2019:5935279.

3: Chen J, Du F, Dang Y, Li X, Qian M, Feng W, Qiao C, Fan D, Nie Y, Wu K, Xia
L. Fibroblast Growth Factor 19-Mediated Up-regulation of SYR-Related High-
Mobility Group Box 18 Promotes Hepatocellular Carcinoma Metastasis by
Transactivating Fibroblast Growth Factor Receptor 4 and Fms-Related Tyrosine
Kinase 4. Hepatology. 2020 May;71(5):1712-1731.

4: Ramos MI, Perez SG, Aarrass S, Helder B, Broekstra P, Gerlag DM, Reedquist
KA, Tak PP, Lebre MC. FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in
rheumatoid arthritis. Arthritis Res Ther. 2013;15(6):R209.

5: Li F, Xu Y, Xu X, Xu B, Zhao J, Zhang X. Fms-related_tyrosine kinase 3 ligand
promotes proliferation of placenta amnion and chorion mesenchymal stem cells
in vitro. Mol Med Rep. 2014 Jul;10(1):322-8.

6: Williams P, Basu S, Garcia-Manero G, Hourigan CS, Oetjen KA, Cortes JE,
Ravandi F, Jabbour EJ, Al-Hamal Z, Konopleva M, Ning J, Xiao L, Hidalgo Lopez J,
Kornblau SM, Andreeff M, Flores W, Bueso-Ramos C, Blando J, Galera P, Calvo KR,
Al-Atrash G, Allison JP, Kantarjian HM, Sharma P, Daver NG. The distribution of
T-cell subsets and the expression of immune checkpoint receptors and ligands in
patients with newly diagnosed and relapsed acute myeloid leukemia. Cancer. 2019
May 1;125(9):1470-1481.

7: Yang J, Zhang W. New molecular insights into osteosarcoma targeted therapy.
Curr Opin Oncol. 2013 Jul;25(4):398-406.
8: Huang Y, Ratajczak MZ, Reca R, Xu H, Tanner M, Rezzoug F, Hussain LR, Fugier-
Vivier I, Bolli R, Ildstad ST. Fms-related tyrosine kinase 3 expression
discriminates hematopoietic stem cells subpopulations with differing
engraftment-potential: identifying the most potent combination. Transplantation.
2008 Apr 27;85(8):1175-84.

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