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Fluorgenic Caspase 8 Substrate 1f

$595.00

Catalog Number: B2011315 (2.5 mg)
Fluorgenic Caspase 8 Substrate 1f is a high quality AFC (7-amino-4-trifluoromethylcoumarin)-derived caspase substrates. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2011315 Categories: ,

Description

Fluorgenic Caspase 8 Substrate 1f
Catalog number: B2011315
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2.5 mg
Molecular Weight or Concentration: 729.7 g/mp;
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Caspase-8 substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Reszka P, Schulz R, Methling K, Lalk M, Bednarski PJ. Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates ChemMedChem. 2010 Jan;5(1):103-17.
2: Weglarczyk K, Baran J, Zembala M, Pryjma J. Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus Infect Immun. 2004 May;72(5):2590-7.
3: Nagase M, Shiota T, Tsushima A, Murshedul Alam M, Fukuoka S, Yoshizawa T, Sakato N. Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3 Immunol Lett. 2002 Oct 21;84(1):23-7.
4: Packard BZ, Komoriya A, Brotz TM, Henkart PA. Caspase 8 activity in membrane blebs after anti-Fas ligation J Immunol. 2001 Nov 1;167(9):5061-6.
5: Li X, Zhao Y, Zhang Y, Du N, Ren H. Tumor necrosis factor α stimulates Her-2 cleavage by activated caspase-8 Cell Physiol Biochem. 2012;30(4):889-97.
6: Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M. Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells Cell Death Differ. 2019 Dec;26(12):2695-2709.
7: Inohara N, Koseki T, Hu Y, Chen S, Núñez G. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10717-22.
8: Park EJ, Shin JW, Seo YS, Kim DW, Hong SY, Park WI, Kang BM. Gonadotropin-releasing hormone-agonist induces apoptosis of human granulosa-luteal cells via caspase-8, -9 and -3, and poly-(ADP-ribose)-polymerase cleavage Biosci Trends. 2011;5(3):120-8.
9: Rokhlin OW, Guseva NV, Tagiyev AF, Glover RA, Cohen MB. Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP Prostate. 2002 Jun 1;52(1):1-11.
10: Roy S, Sharom JR, Houde C, Loisel TP, Vaillancourt JP, Shao W, Saleh M, Nicholson DW. Confinement of caspase-12 proteolytic activity to autoprocessing Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4133-8.

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