Fluorescein Isothiocyanate Dextran


Catalog Number: B2011419 (25 mg)
Fluorescein Isothiocyanate Dextran is a high quality fluorescent probe to study cell permeability. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Fluorescein Isothiocyanate Dextran
Catalog number: B2011419
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 mg
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: 2-8 °C
Keywords: FITC-Dextran 4
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Natarajan R, Northrop N, Yamamoto B. Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability Curr Protoc Neurosci. 2017 Apr 10;79:9.58.1-9.58.15.
2: Vuong CN, Mullenix GJ, Kidd MT, Bottje WG, Hargis BM, Tellez-Isaias G. Research Note: Modified serum fluorescein isothiocyanate dextran (FITC-d) assay procedure to determine intestinal permeability in poultry fed diets high in natural or synthetic pigments Poult Sci. 2021 Jun;100(6):101138.
3: Ohkuma S. Use of fluorescein isothiocyanate-dextran to measure proton pumping in lysosomes and related organelles Methods Enzymol. 1989;174:131-54.
4: Miyamoto H, Tsuda K, Honda T, Tokunaga A, Fumoto S, Nishida K. Influence of Liver Intoxication by Carbon Tetrachloride or D-Galactosamine on Absorption of Fluorescein Isothiocyanate_Dextran-10 and Other Marker Compounds with Different Molecular Weights from the Rat Liver Surface Biol Pharm Bull. 2020;43(2):319-324.
5: Feng Y, Huang Y, Wang Y, Wang P, Song H, Wang F. Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy PLoS One. 2019 Jun 18;14(6):e0218384.
6: Maeda T, Yamamoto Y, Iwasaki D, Hayashi T, Funayama E, Oyama A, Murao N, Furukawa H. Lymphatic Reconnection and Restoration of Lymphatic Flow by Nonvascularized Lymph Node Transplantation: Real-Time Fluorescence Imaging Using Indocyanine Green and Fluorescein Isothiocyanate_Dextran Lymphat Res Biol. 2018 Apr;16(2):165-173.
7: Araie M, Maurice DM. The loss of fluorescein, fluorescein glucuronide and fluorescein isothiocyanate_dextran from the vitreous by the anterior and retinal pathways Exp Eye Res. 1991 Jan;52(1):27-39.
8: Hoogstraate AJ, Verhoef JC, Tuk B, Pijpers A, van Leengoed LA, Verheijden JH, Junginger HE, Boddé HE. In-vivo buccal delivery of fluorescein isothiocyanate_dextran 4400 with glycodeoxycholate as an absorption enhancer in pigs J Pharm Sci. 1996 May;85(5):457-60.
9: Horita D, Yoshimoto M, Todo H, Sugibayashi K. Analysis of hair follicle penetration of lidocaine and fluorescein isothiocyanate_dextran 4 kDa using hair follicle-plugging method Drug Dev Ind Pharm. 2014 Mar;40(3):345-51.
10: Purandare S, Offenbartl K, Weström B, Bengmark S. Increased gut permeability to fluorescein isothiocyanate-dextran after total parenteral nutrition in the rat Scand J Gastroenterol. 1989 Aug;24(6):678-82.

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Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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