E3 Ligand-linker Conjugate 5

Description

E3 Ligand-linker Conjugate 5
Catalog number: B2012901
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 315.4 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: E3 Ligand linker Conjugate 5
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sosič I, Bricelj A, Steinebach C. E3 ligase ligand chemistries: from building blocks to protein degraders Chem Soc Rev. 2022 May 10;51(9):3487-3534.
2: Bricelj A, Steinebach C, Kuchta R, Gütschow M, Sosič I. E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points Front Chem. 2021 Jul 5;9:707317.
3: Wang C, Zhang Y, Wu Y, Xing D. Developments of CRBN-based PROTACs as potential therapeutic agents Eur J Med Chem. 2021 Dec 5;225:113749.
4: Khan S, He Y, Zhang X, Yuan Y, Pu S, Kong Q, Zheng G, Zhou D. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics Oncogene. 2020 Jun;39(26):4909-4924.
5: Scheepstra M, Hekking KFW, van Hijfte L, Folmer RHA. Bivalent Ligands for Protein Degradation in Drug Discovery Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
6: Nieto-Jiménez C, Morafraile EC, Alonso-Moreno C, Ocaña A. Clinical considerations for the design of PROTACs in cancer Mol Cancer. 2022 Mar 7;21(1):67.
7: Weng G, Shen C, Cao D, Gao J, Dong X, He Q, Yang B, Li D, Wu J, Hou T. PROTAC-DB: an online database of PROTACs Nucleic Acids Res. 2021 Jan 8;49(D1):D1381-D1387.
8: Konstantinidou M, Li J, Zhang B, Wang Z, Shaabani S, Ter Brake F, Essa K, Dömling A. PROTACs- a game-changing technology Expert Opin Drug Discov. 2019 Dec;14(12):1255-1268.
9: Guenette RG, Yang SW, Min J, Pei B, Potts PR. Target and tissue selectivity of PROTAC degraders Chem Soc Rev. 2022 Jul 18;51(14):5740-5756.
10: Fischer F, Alves Avelar LA, Murray L, Kurz T. Designing HDAC-PROTACs: lessons learned so far Future Med Chem. 2022 Jan;14(3):143-166.

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