Dityrosine (Highly Pure)

Product Description

Dityrosine (Highly Pure)
Catalog number: B2017556
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 ug
Molecular Weight or Concentration: 433.3
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: Bityrosine, o,o-Ditryosine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Bartesaghi S, Wenzel J, Trujillo M, López M, Joseph J, Kalyanaraman B, Radi R. Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes Chem Res Toxicol. 2010 Apr 19;23(4):821-35.
2: Arenas A, López-Alarcón C, Kogan M, Lissi E, Davies MJ, Silva E. Chemical modification of lysozyme, glucose 6-phosphate dehydrogenase, and bovine eye lens proteins induced by peroxyl radicals: role of oxidizable amino acid residues Chem Res Toxicol. 2013 Jan 18;26(1):67-77.
3: Polimova AM, Vladimirova GA, Proskurnina EV, Vladimirov IuA. [Antioxidants as aromatic amino acid oxidation products] Biofizika. 2011 Jul-Aug;56(4):581-6.
4: Maina MB, Al-Hilaly YK, Serpell LC. Dityrosine cross-linking and its potential roles in Alzheimer’s disease Front Neurosci. 2023 Mar 22;17:1132670.
5: Li B, Yang Y, Ding Y, Ge Y, Xu Y, Xie Y, Shi Y, Le G. Dityrosine in food: A review of its occurrence, health effects, detection methods, and mitigation strategies Compr Rev Food Sci Food Saf. 2023 Jan;22(1):355-379.
6: Malencik DA, Anderson SR. Dityrosine as a product of oxidative stress and fluorescent probe Amino Acids. 2003 Dec;25(3-4):233-47.
7: Vázquez G, Caballero AB, Kokinda J, Hijano A, Sabaté R, Gamez P. Copper, dityrosine cross-links and amyloid-β aggregation J Biol Inorg Chem. 2019 Dec;24(8):1217-1229.
8: Sahin C, Østerlund EC, Österlund N, Costeira-Paulo J, Pedersen JN, Christiansen G, Nielsen J, Grønnemose AL, Amstrup SK, Tiwari MK, Rao RSP, Bjerrum MJ, Ilag LL, Davies MJ, Marklund EG, Pedersen JS, Landreh M, Møller IM, Jørgensen TJD, Otzen DE. Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization J Am Chem Soc. 2022 Jul 13;144(27):11949-11954.
9: Gidwani SV, Brahmbhatt D, Zomback A, Bassie M, Martinez J, Zhuang J, Schulze J, McLellan JS, Mariani R, Alff P, Frasca D, Blomberg BB, Marshall CP, Yondola MA. Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages Nat Commun. 2024 Mar 14;15(1):2202.
10: Maina MB, Al-Hilaly YK, Oakley S, Burra G, Khanom T, Biasetti L, Mengham K, Marshall K, Harrington CR, Wischik CM, Serpell LC. Dityrosine Cross-links are Present in Alzheimer’s Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro J Mol Biol. 2022 Oct 15;434(19):167785.

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