DiBAC4(3) (Bis-(1,3-dibutylbarbituric acid)trimethine oxonol)


Catalog Number: B2011425 (5 mg)
DiBAC4(3) (Bis-(1,3-dibutylbarbituric acid)trimethine oxonol) is a high quality membrane potential probe that can bind to intracellular proteins. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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DiBAC4(3) (Bis-(1,3-dibutylbarbituric acid)trimethine oxonol)
Catalog number: B2011425
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 516.6 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: [Bis-(1,3-dibutylbarbituric acid)trimethine oxonol]
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Scornik FS, Bucciero RS, Wu Y, Selga E, Bosch Calero C, Brugada R, Pérez GJ. DiBAC₄(3) hits a “sweet spot” for the activation of arterial large-conductance Ca²⁺-activated potassium channels independently of the β₁-subunit Am J Physiol Heart Circ Physiol. 2013 Jun 1;304(11):H1471-82.
2: Yamada A, Gaja N, Ohya S, Muraki K, Narita H, Ohwada T, Imaizumi Y. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells Jpn J Pharmacol. 2001 Jul;86(3):342-50.
3: Bosch Calero C, Selga E, Brugada R, Scornik FS, Pérez GJ. The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels Channels (Austin). 2014;8(1):95-102.
4: Oviedo NJ, Nicolas CL, Adams DS, Levin M. Live Imaging of Planarian Membrane Potential Using DiBAC4(3) CSH Protoc. 2008 Oct 1;2008:pdb.prot5055.
5: Epps DE, Wolfe ML, Groppi V. Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells Chem Phys Lipids. 1994 Feb;69(2):137-50.
6: Adams DS, Levin M. Measuring resting membrane potential using the fluorescent voltage reporters DiBAC4(3) and CC2-DMPE Cold Spring Harb Protoc. 2012 Apr 1;2012(4):459-64.
7: Ding XY, Fang LQ, Zhang H, Qiao H, Wang ZB. [Study of DiBAC4(3) for dynamic measurement of embryo membrane potentials] Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Jan;28(1):32-3, 78.
8: López-Amorós R, Castel S, Comas-Riu J, Vives-Rego J. Assessment of E. coli and Salmonella viability and starvation by confocal laser microscopy and flow cytometry using rhodamine 123, DiBAC4(3), propidium iodide, and CTC Cytometry. 1997 Dec 1;29(4):298-305.
9: Lee W, Lee DG. Fungicidal mechanisms of the antimicrobial peptide Bac8c Biochim Biophys Acta. 2015 Feb;1848(2):673-9.
10: Lee H, Ji YR, Ryoo ZY, Choi MS, Woo ER, Lee DG. Antibacterial Mechanism of (-)-Nortrachelogenin in Escherichia coli O157 Curr Microbiol. 2016 Jan;72(1):48-54.

Products Related to DiBAC4(3) (Bis-(1,3-dibutylbarbituric acid)trimethine oxonol) can be found at Dyes

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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