[D-Trp8]-Somatostatin

Product Description

[D-Trp8]-Somatostatin
Catalog number: MDP0473
CAS Number: 106362-32-7
Sequence: Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bond between Cys3-Cys14)
Amount: 500 ug
Molecular Weight: 1637.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Vécsei L, Bollók I, Penke B, Telegdy G. Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats Psychoneuroendocrinology. 1986;11(1):111-5.
2: Felix AM, Jimenez MH, Wang CT, Meienhofer J. Synthesis of somatostatin and [D-Trp8]-somatostatin Int J Pept Protein Res. 1980 Apr;15(4):342-54.
3: Dokas LA, Klis M, Liauw A, Coy DH. Characteristics of [D-Trp8]-somatostatin-sensitive B50 phosphorylation Peptides. 1985 Nov-Dec;6(6):1101-7.
4: Rivier J, Brown M, Vale W. D-Trp8-somatostatin: an analog of somatostatin more potent than the native molecule Biochem Biophys Res Commun. 1975 Jul 22;65(2):746-51.
5: Chernish SM, Miller RE, Rosenak BD, Brunelle RL. Effect of D-Val1, D-Trp8-somatostatin on the motility of the stomach, duodenum and jejunum Am J Gastroenterol. 1981 Jan;75(1):36-40.
6: Neelamkavil S, Arison B, Birzin E, Feng JJ, Chen KH, Lin A, Cheng FC, Taylor L, Thornton ER, Smith AB 3rd, Hirschmann R. Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol J Med Chem. 2005 Jun 16;48(12):4025-30.
7: Cohen ML, Wiley KS, Yaden E, Slater IH. In vitro actions of somatostatin, D-Val1, D-Trp8-somatostatin and glucagon in rabbit jejunum and guinea-pig ileum J Pharmacol Exp Ther. 1979 Nov;211(2):423-9.
8: Epelbaum J, Bluet-Pajot MT, Llorens-Cortes C, Kordon C, Mounier F, Senut MC, Videau C. 125I-[Tyr0,D-Trp8]somatostatin-14 binding sites in the locus coeruleus of the rat are located on both ascending and descending projecting noradrenergic cells Peptides. 1990 Jan-Feb;11(1):21-7.
9: Brown M, Rivier J, Vale W. Somatostatin: analogs with selected biological activities Science. 1977 Jun 24;196(4297):1467-9.
10: Rivier JE, Brown MR, Vale WW. Tyrosylated analogues of somatostatin J Med Chem. 1976 Aug;19(8):1010-3.

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