Clasto-Lactacystin β-lactone (Highly Pure)


Catalog Number: B2010436 (0.1 mg)
Clasto-Lactacystin β-lactone is a highly pure Clasto-Lactacystin β-lactone. This compound has been used as a proteasomal inhibitor. Custom bulk orders of this product are available upon request.
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SKU: B2010436 Categories: , ,


Clasto-Lactacystin β-lactone
Catalog number: B2010436
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 0.1 mg
Molecular Weight or Concentration: 213.23
Supplied as: Film
Appearance: Film
Applications: Highly pure Clasto-Lactacystin β-lactone. This compound has been used as a proteasomal inhibitor.
Storage: -20C
Keywords: clasto Lactacystin β-lactone
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Dick LR, Cruikshank AA, Grenier L, Melandri FD, Nunes SL, Stein RL.
Mechanistic studies on the inactivation of the proteasome by lactacystin: a
central role for clasto-lactacystin beta-lactone. J Biol Chem. 1996 Mar

2: Craiu A, Gaczynska M, Akopian T, Gramm CF, Fenteany G, Goldberg AL, Rock KL.
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-
subunits and inhibit intracellular protein degradation and major
histocompatibility complex class I antigen presentation. J Biol Chem. 1997 May

3: Kirkland PA, Reuter CJ, Maupin-Furlow JA. Effect of proteasome inhibitor
clasto-lactacystin-beta-lactone on the proteome of the haloarchaeon Haloferax
volcanii. Microbiology (Reading). 2007 Jul;153(Pt 7):2271-2280.

4: Hayes CJ, Sherlock AE, Selby MD. Enantioselective total syntheses of
(-)-clasto-lactacystin beta-lactone and 7-epi-(-)-clasto-lactacystin beta-
lactone. Org Biomol Chem. 2006 Jan 21;4(2):193-5.

5: Aikawa S, Matsuzawa F, Satoh Y, Kadota Y, Doi H, Itoh K. Prediction of the
mechanism of action of omuralide (clasto-lactacystin beta-lactone) on human
cathepsin A based on a structural model of the yeast proteasome
beta5/PRE2-subunit/omuralide complex. Biochim Biophys Acta. 2006

6: Donohoe TJ, Sintim HO, Sisangia L, Ace KW, Guyo PM, Cowley A, Harling JD.
Utility of the ammonia-free Birch reduction of electron-deficient pyrroles:
total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-
lactone. Chemistry. 2005 Jul 4;11(14):4227-38.

7: Levine SJ, Adamik B, Hawari FI, Islam A, Yu ZX, Liao DW, Zhang J, Cui X,
Rouhani FN. Proteasome inhibition induces TNFR1 shedding from human airway
epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2005

8: Fenteany G, Standaert RF, Reichard GA, Corey EJ, Schreiber SL. A beta-lactone
related to lactacystin induces neurite outgrowth in a neuroblastoma cell line
and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad
Sci U S A. 1994 Apr 12;91(8):3358-62.

9: Fukuchi K, Maruyama H, Takagi Y, Gomi K. Direct proteasome inhibition by
clasto-lactacystin beta-lactone permits the detection of ubiquitinated p21(waf1)
in ML-1 cells. Biochim Biophys Acta. 1999 Aug 12;1451(1):206-10.
10: Troyner F, Bertoglio LJ. Thalamic nucleus reuniens regulates fear memory
destabilization upon retrieval. Neurobiol Learn Mem. 2020 Nov;175:107313.

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