Chromogenic Substrate for Factor XI and Activated Protein C

Product Description

Chromogenic Substrate for Factor XI and Activated Protein C
Catalog number: B2014477
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5mg
Molecular Weight or Concentration: 539
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: Chromogenic Substrate for Factor XI and Activated Protein C
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Retzios AD, Rosenfeld R, Schiffman S. Enzymes of the contact phase of blood coagulation: kinetics with various chromogenic substrates and a two-substrate assay for the joint estimation of plasma prekallikrein and factor XI J Lab Clin Med. 1988 Nov;112(5):560-6.
2: Puy C, Ngo ATP, Pang J, Keshari RS, Hagen MW, Hinds MT, Gailani D, Gruber A, Lupu F, McCarty OJT. Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI) Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1390-1401.
3: Scott CF, Colman RW. A simple and accurate microplate assay for the determination of factor XI in plasma J Lab Clin Med. 1988 Jun;111(6):708-14.
4: Citarella F, Fedele G, Roem D, Fantoni A, Hack CE. The second exon-encoded factor XII region is involved in the interaction of factor XII with factor XI and does not contribute to the binding site for negatively charged surfaces Blood. 1998 Dec 1;92(11):4198-206.
5: Tans G, Janssen-Claessen T, Rosing J, Griffin JH. Studies on the effect of serine protease inhibitors on activated contact factors. Application in amidolytic assays for factor XIIa, plasma kallikrein and factor XIa Eur J Biochem. 1987 May 4;164(3):637-42.
6: Aiyappa PA. Chromogenic substrate spectrophotometric assays for the measurement of clotting function Ann N Y Acad Sci. 1981;370:812-21.
7: Kuder H, Dickeson SK, Brooks MB, Kehl A, Müller E, Gailani D, Giger U. A Common Missense Variant Causing Factor XI Deficiency and Increased Bleeding Tendency in Maine Coon Cats Genes (Basel). 2022 Apr 28;13(5):792.
8: Al-Horani RA, Parsaeian E, Mohammad M, Mottamal M. Sulfonated non-saccharide molecules and human factor XIa: Enzyme inhibition and computational studies Chem Biol Drug Des. 2022 Jul;100(1):64-79.
9: Zucker M, Seligsohn U, Yeheskel A, Mor-Cohen R. An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase J Thromb Haemost. 2016 Nov;14(11):2202-2211.
10: Nakamura M, Takeuchi T, Kawahara T, Hirose J, Nakayama K, Hosaka Y, Furusako S. Simultaneous targeting of CD14 and factor XIa by a fusion protein consisting of an anti-CD14 antibody and the modified second domain of bikunin improves survival in rabbit sepsis models Eur J Pharmacol. 2017 May 5;802:60-68.

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