CGRP (Human, 8-37)

Product Description

CGRP (Human, 8-37)
Catalog number: MDP0617
CAS Number: N/A
Sequence: Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
Amount: 500 ug
Molecular Weight: 3125.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Paige C, Plasencia-Fernandez I, Kume M, Papalampropoulou-Tsiridou M, Lorenzo LE, David ET, He L, Mejia GL, Driskill C, Ferrini F, Feldhaus AL, Garcia-Martinez LF, Akopian AN, De Koninck Y, Dussor G, Price TJ. A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models J Neurosci. 2022 Mar 9;42(10):1930-1944.
2: Chiba T, Yamaguchi A, Yamatani T, Nakamura A, Morishita T, Inui T, Fukase M, Noda T, Fujita T. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37) Am J Physiol. 1989 Feb;256(2 Pt 1):E331-5.
3: Gardiner SM, Compton AM, Kemp PA, Bennett T, Bose C, Foulkes R, Hughes B. Antagonistic effect of human alpha-CGRP -29 on the in vivo regional haemodynamic actions of human alpha-CGRP Biochem Biophys Res Commun. 1990 Sep 28;171(3):938-43.
4: Verheggen R, Wojtas K, Webel M, Hoffmann S, Kaumann AJ. BIBN4096BS and CGRP(8-37) antagonize the relaxant effects of alpha-CGRP more than those of beta-CGRP in human extracranial arteries Naunyn Schmiedebergs Arch Pharmacol. 2005 May;371(5):383-92.
5: Chakder S, Rattan S. Antagonism of calcitonin gene-related peptide (CGRP) by human CGRP-(8-37): role of CGRP in internal anal sphincter relaxation J Pharmacol Exp Ther. 1991 Mar;256(3):1019-24.
6: Verheggen R, Bumann K, Kaumann AJ. BIBN4096BS is a potent competitive antagonist of the relaxant effects of alpha-CGRP on human temporal artery: comparison with CGRP(8-37) Br J Pharmacol. 2002 May;136(1):120-6.
7: Lawson DC, Mantyh CR, Pappas TN. Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog Dig Dis Sci. 1994 Jul;39(7):1405-8.
8: Deems RO, Cardinaux F, Deacon RW, Young DA. Amylin or CGRP (8-37) fragments reverse amylin-induced inhibition of 14C-glycogen accumulation Biochem Biophys Res Commun. 1991 Nov 27;181(1):116-20.
9: Silvestre RA, Salas M, Dégano P, Peiró E, Marco J. Reversal of the inhibitory effects of calcitonin gene-related peptide (CGRP) and amylin on insulin secretion by the 8-37 fragment of human CGRP Biochem Pharmacol. 1993 Jun 9;45(11):2343-7.
10: Young A. Receptor pharmacology Adv Pharmacol. 2005;52:47-65.

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