CDK5 Substrate (Highly Pure)

Product Description

CDK5 Substrate (Highly Pure)
Catalog number: B2011195
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1138.5 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: cyclin-dependent kinase 5
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Terse A, Amin N, Hall B, Bhaskar M, B K B, Utreras E, Pareek TK, Pant H, Kulkarni AB. Protocols for Characterization of Cdk5 Kinase Activity Curr Protoc. 2021 Oct;1(10):e276.
2: Liu SL, Wang C, Jiang T, Tan L, Xing A, Yu JT. The Role of Cdk5 in Alzheimer’s Disease Mol Neurobiol. 2016 Sep;53(7):4328-42.
3: Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Yin Z, Zhang J. CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis J Exp Clin Cancer Res. 2019 Jul 4;38(1):286.
4: Yamada M, Saito T, Sato Y, Kawai Y, Sekigawa A, Hamazumi Y, Asada A, Wada M, Doi H, Hisanaga SI. Cdk5–p39 is a labile complex with the similar substrate specificity to Cdk5–p35 J Neurochem. 2007 Sep;102(5):1477-1487.
5: De S, Holvey-Bates EG, Mahen K, Willard B, Stark GR. The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2112674118.
6: Cortés N, Guzmán-Martínez L, Andrade V, González A, Maccioni RB. CDK5: A Unique CDK and Its Multiple Roles in the Nervous System J Alzheimers Dis. 2019;68(3):843-855.
7: Shukla V, Skuntz S, Pant HC. Deregulated Cdk5 activity is involved in inducing Alzheimer’s disease Arch Med Res. 2012 Nov;43(8):655-62.
8: Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H. CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity Nat Commun. 2019 Sep 5;10(1):4013.
9: Shah K, Rossie S. Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain Mol Neurobiol. 2018 Apr;55(4):3426-3438.
10: Sulak MA, Ghosh M, Sinharoy P, Andrei SR, Damron DS. Modulation of TRPA1 channel activity by Cdk5 in sensory neurons Channels (Austin). 2018 Jan 1;12(1):65-75.

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