CDK5 Substrate – (5-TMR) labeled

Product Description

CDK5 Substrate – (5-TMR) labeled
Catalog number: B2019514
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1551
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: 5-TMR-PKTPKKAKKL
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5 Neuron. 2012 Aug 23;75(4):675-87.
3: Cho DH, Seo J, Park JH, Jo C, Choi YJ, Soh JW, Jo I. Cyclin-dependent kinase 5 phosphorylates endothelial nitric oxide synthase at serine 116 Hypertension. 2010 Feb;55(2):345-52.
4: Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron. 2003 Oct 30;40(3):471-83.
5: Nguyen MD, Larivière RC, Julien JP. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions Neuron. 2001 Apr;30(1):135-47.
6: Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity Neuron. 2008 May 22;58(4):571-83.
7: Zambrano CA, Egaña JT, Núñez MT, Maccioni RB, González-Billault C. Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1 Free Radic Biol Med. 2004 Jun 1;36(11):1393-402.
8: Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn J Neurosci. 2016 Nov 2;36(44):11208-11222.
9: Yeh CW, Hsu LS. Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway Mol Neurobiol. 2016 Dec;53(10):6594-6607.
10: Nehmé R, Nehmé H, Roux G, Destandau E, Claude B, Morin P. Capillary electrophoresis as a novel technique for screening natural flavonoids as kinase inhibitors J Chromatogr A. 2013 Nov 29;1318:257-64.

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