Castanospermine (Highly Pure)

Product Description

Castanospermine (Highly Pure)
Catalog number: B2012508
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 189.2 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: 6,7-Diepicastanospermine, 6-Epicastanospermine, 1,6,7,8-Tetrahydroxyoctahydroindolizine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Noda N, Ozawa T. Castanospermine suppresses CD44 ectodomain cleavage as revealed by transmembrane bioluminescent sensors J Cell Sci. 2022 Mar 15;135(6):jcs259314.
2: Clarke EC, Nofchissey RA, Ye C, Bradfute SB. The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication Glycobiology. 2021 May 3;31(4):378-384.
3: Myeong IS, Lee YT, Kang J, Ham WH. Stereoselective Total Syntheses of (+)-Castanospermine and Neu5Ac Methyl Ester J Org Chem. 2019 Apr 5;84(7):4211-4220.
4: Hibberd AD, Clark DA, Trevillian PR, Mcelduff P. Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation World J Transplant. 2016 Mar 24;6(1):206-14.
5: Tharappel AM, Cheng Y, Holmes EH, Ostrander GK, Tang H. Castanospermine_ reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models Antiviral Res. 2020 Nov;183:104935.
6: Yun H, Kim J, Sim J, Lee S, Han YT, Chang DJ, Kim DD, Suh YG. Asymmetric syntheses of 1-deoxy-6,8a-di-epi-castanospermine and 1-deoxy-6-epi-castanospermine J Org Chem. 2012 Jun 15;77(12):5389-93.
7: Saul R, Chambers JP, Molyneux RJ, Elbein AD. Castanospermine_, a tetrahydroxylated alkaloid that inhibits beta-glucosidase and beta-glucocerebrosidase Arch Biochem Biophys. 1983 Mar;221(2):593-7.
8: Whitby K, Pierson TC, Geiss B, Lane K, Engle M, Zhou Y, Doms RW, Diamond MS. Castanospermine_, a potent inhibitor of dengue virus infection in vitro and in vivo J Virol. 2005 Jul;79(14):8698-706.
9: Pan YT, Hori H, Saul R, Sanford BA, Molyneux RJ, Elbein AD. Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin Biochemistry. 1983 Aug 2;22(16):3975-84.
10: Allan G, Ouadid-Ahidouch H, Sanchez-Fernandez EM, Risquez-Cuadro R, Fernandez JM, Ortiz-Mellet C, Ahidouch A. New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells PLoS One. 2013 Oct 4;8(10):e76411.

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