Caspase Substrate

Product Description

Caspase Substrate
Catalog number: B2014423
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2 mg
Molecular Weight or Concentration: 754.76 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: Caspase Substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling ACS Chem Biol. 2021 Nov 19;16(11):2280-2296.
2: McIlwain DR, Berger T, Mak TW. Caspase functions in cell death and disease Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a008656.
3: Julien O, Wells JA. Caspases and their substrates Cell Death Differ. 2017 Aug;24(8):1380-1389.
4: Timmer JC, Salvesen GS. Caspase_substrates Cell Death Differ. 2007 Jan;14(1):66-72.
5: Song Y, Song J, Wang M, Wang J, Ma B, Zhang W. Porcine Gasdermin D Is a Substrate of Caspase_1 and an Executioner of Pyroptosis Front Immunol. 2022 Mar 14;13:828911.
6: Datta D, McClendon CL, Jacobson MP, Wells JA. Substrate_ and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3 J Biol Chem. 2013 Apr 5;288(14):9971-9981.
7: Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase_6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding J Biol Chem. 2017 Mar 24;292(12):4885-4897.
8: Agnew A, Nulty C, Creagh EM. Regulation, Activation and Function of Caspase-11 during Health and Disease Int J Mol Sci. 2021 Feb 3;22(4):1506.
9: Salvesen GS, Riedl SJ. Caspase mechanisms Adv Exp Med Biol. 2008;615:13-23.
10: Ramirez MLG, Poreba M, Snipas SJ, Groborz K, Drag M, Salvesen GS. Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1 J Biol Chem. 2018 May 4;293(18):7058-7067.

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