Caspase-6 Substrate III Fluorogenic


Catalog Number: B2014281 (2 mg)
Caspase-6 Substrate III Fluorogenic is a high quality fluorogenic substrate for caspase-6. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Caspase-6 Substrate III Fluorogenic
Catalog number: B2014281
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2 mg
Molecular Weight or Concentration: 819.78 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: Caspase-6 Substrate III, Fluorogenic
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Huang S, Mei H, Lu L, Kuang Z, Heng Y, Xu L, Liang X, Qiu M, Pan X. Conformational transitions of caspase-6 in substrate-induced activation process explored by perturbation-response scanning combined with targeted molecular dynamics Comput Struct Biotechnol J. 2021 Jul 24;19:4156-4164.
2: Graham RK, Ehrnhoefer DE, Hayden MR. Caspase-6 and neurodegeneration Trends Neurosci. 2011 Dec;34(12):646-56.
3: Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding J Biol Chem. 2017 Mar 24;292(12):4885-4897.
4: Vaidya S, Velzquez-Delgado EM, Abbruzzese G, Hardy JA. Substrate-induced conformational changes occur in all cleaved forms of caspase-6 J Mol Biol. 2011 Feb 11;406(1):75-91.
5: Wang XJ, Cao Q, Zhang Y, Su XD. Activation and regulation of caspase-6 and its role in neurodegenerative diseases Annu Rev Pharmacol Toxicol. 2015;55:553-72.
6: Velzquez-Delgado EM, Hardy JA. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove Structure. 2012 Apr 4;20(4):742-51.
7: MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis J Biol Chem. 2019 Jan 4;294(1):71-88.
8: Bi X, Liu X, Bi D, Sun Y. Identification of Caspase-6 and Caspase-7 from miiuy croaker and evolution analysis in fish Fish Shellfish Immunol. 2018 Dec;83:406-409.
9: Soares J, Lowe MM, Jarstfer MB. The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate Biochemistry. 2011 Oct 25;50(42):9046-55.
10: Arnault E, Doussau M, Pesty A, Lefvre B, Courtot AM. Review: Lamin A/C, caspase-6, and chromatin configuration during meiosis resumption in the mouse oocyte Reprod Sci. 2010 Feb;17(2):102-15.

Products Related to Caspase-6 Substrate III Fluorogenic can be found at Substrates

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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