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Candidalysin (Highly Pure)

$395.00

Catalog Number: MDP0845 (0.1 mg)

High purity Candidalysin (> 95% by HPLC). Candidalysin is a fungal cytolytic peptide secreted by  Candida albicans. This peptide has many research applications.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: MDP0845 Category: Tag:

Description

Candidalysin (Highly Pure)
Catalog number: MDP0845
Name: Ser-Ile-Ile-Gly-Ile-Ile-Met-Gly-Ile-Leu-Gly-Asn-Ile-Pro-Gln-Val-Ile-Gln-Ile-Ile-Met-Ser-Ile-Val-Lys-Ala-Phe-Lys-Gly-Asn-Lys
Other name(s): Candidalysin
Molecular Formula: C153H266N38O38S2
Molecular Mass: 3310.1
Storage Temperature: -20 C
Indication for Use:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

Safety:
User must review the Safety Data Sheet (MSDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes.

References:

1: Ho J, Camilli G, Griffiths JS, Richardson JP, Kichik N, Naglik JR. Candida albicans and candidalysin in inflammatory disorders and cancer Immunology. 2021 Jan;162(1):11-16.
2: Chu H, Duan Y, Lang S, Jiang L, Wang Y, Llorente C, Liu J, Mogavero S, Bosques-Padilla F, Abraldes JG, Vargas V, Tu XM, Yang L, Hou X, Hube B, Stärkel P, Schnabl B. The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease J Hepatol. 2020 Mar;72(3):391-400.
3: Naglik JR, Gaffen SL, Hube B. Candidalysin: discovery and function in Candida albicans infections Curr Opin Microbiol. 2019 Dec;52:100-109.
4: Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR. Candidalysin is a fungal peptide toxin critical for mucosal infection Nature. 2016 Apr 7;532(7597):64-8.
5: Blagojevic M, Camilli G, Maxson M, Hube B, Moyes DL, Richardson JP, Naglik JR. Candidalysin triggers epithelial cellular stresses that induce necrotic death Cell Microbiol. 2021 Oct;23(10):e13371.
6: Engku Nasrullah Satiman EAF, Ahmad H, Ramzi AB, Abdul Wahab R, Kaderi MA, Wan Harun WHA, Dashper S, McCullough M, Arzmi MH. The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis J Oral Pathol Med. 2020 Oct;49(9):835-841.
7: Ho J, Yang X, Nikou SA, Kichik N, Donkin A, Ponde NO, Richardson JP, Gratacap RL, Archambault LS, Zwirner CP, Murciano C, Henley-Smith R, Thavaraj S, Tynan CJ, Gaffen SL, Hube B, Wheeler RT, Moyes DL, Naglik JR. Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor Nat Commun. 2019 May 24;10(1):2297.
8: Mogavero S, Sauer FM, Brunke S, Allert S, Schulz D, Wisgott S, Jablonowski N, Elshafee O, Krüger T, Kniemeyer O, Brakhage AA, Naglik JR, Dolk E, Hube B. Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans Cell Microbiol. 2021 Oct;23(10):e13378.
9: Swidergall M, Khalaji M, Solis NV, Moyes DL, Drummond RA, Hube B, Lionakis MS, Murdoch C, Filler SG, Naglik JR. Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection J Infect Dis. 2019 Sep 26;220(9):1477-1488.

10: Rogiers O, Frising UC, Kucharíková S, Jabra-Rizk MA, van Loo G, Van Dijck P, Wullaert A. Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae mBio. 2019 Jan 8;10(1):e02221-18.

Products Related to Candidalysin: Peptides

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