Big Endothelin-3 (Human, 1-41 Amide)

Product Description

Big Endothelin-3 (Human, 1-41 Amide)
Catalog number: MDP0611
CAS Number: 71800-36-7
Sequence: Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Ile-Asn-Thr-Pro-Glu-Gln-Thr-Val-Pro-Tyr-Gly-Leu-Ser-Asn-Tyr-Arg-Gly-Ser-Phe-Arg-NH2 (Disulfide bonds between Cys1-Cys15 and Cys3-Cys11)
Amount: 100 ug
Molecular Weight: 4923.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Read AP, Newton VE. Waardenburg syndrome J Med Genet. 1997 Aug;34(8):656-65.
2: Ferro CJ, Strachan FE, Shepherd E, Haynes WG, Webb DJ. Big endothelin-3 constricts forearm resistance vessels but not hand veins in humans Clin Pharmacol Ther. 2000 Jul;68(1):67-74.
3: Miyauchi Y, Sakai S, Maeda S, Shimojo N, Watanabe S, Honma S, Kuga K, Aonuma K, Miyauchi T. Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease Life Sci. 2012 Oct 15;91(13-14):729-32.
4: Pawolski V, Schmidt MHH. Neuron-Glia Interaction in the Developing and Adult Enteric Nervous System Cells. 2020 Dec 31;10(1):47.
5: Monti L, Arrigucci U, Rossi A. Insights into Endothelin-3 and Multiple Sclerosis Biomol Concepts. 2020 Jun 25;11(1):137-141.
6: Hasegawa H, Hiki K, Sawamura T, Aoyama T, Okamoto Y, Miwa S, Shimohama S, Kimura J, Masaki T. Purification of a novel endothelin-converting enzyme specific for big endothelin-3 FEBS Lett. 1998 May 29;428(3):304-8.
7: Lee S, Lin M, Mele A, Cao Y, Farmar J, Russo D, Redman C. Proteolytic processing of big endothelin-3 by the kell blood group protein Blood. 1999 Aug 15;94(4):1440-50.
8: Yap EY, Battistini B, McKay KO. Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi Br J Pharmacol. 2000 Jan;129(1):170-6.
9: Monti L, Arrigucci U, Rossi A. Insights into Endothelin-3 and Multiple Sclerosis Biomol Concepts. 2020 Jun 25;11(1):137-141.
10: Cronin NB, Wallace BA. Do the structures of big ET-1 and big ET-3 adopt a similar overall fold? Consequences for endothelin converting enzyme specificity Biochemistry. 1999 Feb 9;38(6):1721-6.

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