Apamin

Product Description

Apamin
Catalog number: MDP0633
CAS Number: 107950-33-4
Sequence: Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bonds between Cys1-Cys11 and Cys3-Cys15)
Amount: 500 ug
Molecular Weight: 2027.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Habermann E. Apamin Pharmacol Ther. 1984;25(2):255-70.
2: Gu H, Han SM, Park KK. Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease Toxins (Basel). 2020 Mar 19;12(3):195.
3: Lazdunski M, Fosset M, Hughes M, Mourre C, Romey G, Schmid-Antomarchi H. The apamin-sensitive Ca2+-dependent K+ channel molecular properties, differentiation and endogenous ligands in mammalian brain Biochem Soc Symp. 1985;50:31-42.
4: Kim W. Bee Venom and Its Sub-Components: Characterization, Pharmacology, and Therapeutics Toxins (Basel). 2021 Mar 7;13(3):191.
5: Lazdunski M. Apamin, a neurotoxin specific for one class of Ca2+-dependent K+ channels Cell Calcium. 1983 Dec;4(5-6):421-8.
6: Kim H, Hong JY, Lee J, Jeon WJ, Ha IH. Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons Toxins (Basel). 2021 Aug 28;13(9):603.
7: Strong PN, Stocker M, Jenkinson DH. Apamin binding proteins and oligosaccharyltransferases Toxicon. 1996 May;34(5):507-9.
8: Proulx É, Power SK, Oliver DK, Sargin D, McLaurin J, Lambe EK. Apamin Improves Prefrontal Nicotinic Impairment in Mouse Model of Alzheimer’s Disease Cereb Cortex. 2020 Mar 21;30(2):563-574.
9: Badr-Eldin SM, Aldawsari HM, Fahmy UA, Ahmed OAA, Alhakamy NA, Al-Hejaili OD, Alhassan AA, Ammari GA, Alhazmi SI, Alawadi RM, Bakhaidar R, Alamoudi AJ, Neamatallah T, Tima S. Optimized Apamin-Mediated Nano-Lipidic Carrier Potentially Enhances the Cytotoxicity of Ellagic Acid against Human Breast Cancer Cells Int J Mol Sci. 2022 Aug 21;23(16):9440.
10: Fattahi H, Esmaeil N, Aliomrani M. Apamin as a BBB Shuttle and Its Effects on T Cell Population During the Experimental Autoimmune Encephalomyelitis-Induced Model of Multiple Sclerosis Neurotox Res. 2021 Dec;39(6):1880-1891.

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