Angiotensin Converting Enzyme II Inhibitor


Catalog Number: B2010520 (2 mg)
Angiotensin Converting Enzyme II Inhibitor is a highly pure synthetic inhibitor of angiotensin converting enzyme 2. This product has been used as molecular tool for various ACE2-related research studies. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Angiotensin Converting Enzyme II Inhibitor
Catalog number: B2010520
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2 mg
Molecular Weight or Concentration: 428.31 g/mol
Supplied as: Powder
Applications: molecular tool for various ACE2-related research studies
Storage: 2-8°C
Keywords: (S, S)-2-(1-Carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid, 2( S)-(1( S)-Carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid, ACE2 Inhibitor
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

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Angiotensin-converting enzyme 2 and angiotensin 1-7: novel therapeutic targets.
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(COVID-19): Do Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor
Blockers Have a Biphasic Effect? J Am Heart Assoc. 2020 Apr 7;9(7):e016509.

6: Natesh R, Schwager SL, Sturrock ED, Acharya KR. Crystal structure of the
human angiotensin-converting enzyme-lisinopril complex. Nature. 2003 Jan

7: Rossi GP, Sanga V, Barton M. Potential harmful effects of discontinuing ACE-
inhibitors and ARBs in COVID-19 patients. Elife. 2020 Apr 6;9:e57278.

8: Pan X, Shao Y, Wu F, Wang Y, Xiong R, Zheng J, Tian H, Wang B, Wang Y, Zhang
Y, Han Z, Qu A, Xu H, Lu A, Yang T, Li X, Xu A, Du J, Lin Z. FGF21 Prevents
Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of
ACE2/Angiotensin-(1-7) Axis in Mice. Cell Metab. 2018 Jun 5;27(6):1323-1337.e5.

9: Simões e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2,
angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. Br J
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10: Deng JL, Jiang YQ, Guo YK, Li HL. Patients taking angiotensin-converting
enzyme inhibitors/angiotensin II type I receptor blockers: higher risks of
severe acute respiratory syndrome coronavirus 2 infection but milder clinical
manifestations? Chin Med J (Engl). 2020 Nov 20;133(22):2650-2652.

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