Acarbose Tridecaacetate (Highly Pure)

Product Description

Acarbose Tridecaacetate (Highly Pure)
Catalog number: B2012741
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 1,192.1 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: O-2,3-Di-O-acetyl-4,6-dideoxy-4-[[4,5,6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1-4)-O-2, 3,6-tri-O-acetyl-a-D-glucopyranosyl-(1-4)-a-D-glucopyranose 1,2,3,6-tetraacetate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Balaich J, Estrella M, Wu G, Jeffrey PD, Biswas A, Zhao L, Korennykh A, Donia MS. The human microbiome encodes resistance to the antidiabetic drug acarbose Nature. 2021 Dec;600(7887):110-115.
2: Dalsgaard NB, Gasbjerg LS, Hansen LS, Hansen NL, Stensen S, Hartmann B, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK. The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes Eur J Endocrinol. 2021 Mar;184(3):383-394.
3: Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M; STOP-NIDDM Trail Research Group. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial Lancet. 2002 Jun 15;359(9323):2072-7.
4: Wang Y, Dai K, Xie K, Weng C. [Biosynthesis and regulatory mechanism of acarbose and its structural analogs: a review] Sheng Wu Gong Cheng Xue Bao. 2022 Feb 25;38(2):605-619.
5: Grudén S, Forslund A, Alderborn G, Söderhäll A, Hellström PM, Holmbäck U. Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose Clin Pharmacol Drug Dev. 2021 Oct;10(10):1242-1247.
6: Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P. Acarbose improved survival for Apc(+/Min) mice Aging Cell. 2020 Feb;19(2):e13088.
7: Wang X, Xu T, Liu R, Wu G, Gu L, Zhang Y, Zhang F, Fu H, Ling Y, Wei X, Luo Y, Shen J, Zhao L, Peng Y, Zhang C, Ding X. High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota Front Endocrinol (Lausanne). 2022 Feb 2;12:806331.
8: Mahmud T, Lee S, Floss HG. The biosynthesis of acarbose and validamycin Chem Rec. 2001;1(4):300-10.
9: Singla RK, Singh R, Dubey AK. Important Aspects of Post-Prandial Antidiabetic Drug, Acarbose Curr Top Med Chem. 2016;16(23):2625-33.
10: Que L, Huang K, Ding Y, Chu N, Yang J, Qian Z, He Q. Acarbose bioequivalence: Exploration of eligible protocol design J Clin Pharm Ther. 2021 Apr;46(2):492-503.

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