6-Deoxy-6-N,N-dimethylamino-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

Product Description

6-Deoxy-6-N,N-dimethylamino-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin
Catalog number: B2027390
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: NA
Supplied as: Chemicals
Storage: −80°C
Keywords: Sugammadex Impurity F, Sugammadex N,N-dimethylamino impurity, Sugammadex USP Impurity F

References:
1. Adam, J. M., Bennett, D. J., Bom, A., Clark, J. K., Feilden, H., Hutchinson, E. J., … & Zhang, M. Q. (2002). Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide. Journal of Medicinal Chemistry, 45(9), 1806-1816.
2. Bom, A., Bradley, M., Cameron, K., Clark, J. K., Van Egmond, J., Feilden, H., … & Zhang, M. Q. (2002). A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a synthetic cyclodextrin-based host. Angewandte Chemie International Edition, 41(2), 265-270.
3. Gijsenbergh, F., Ramael, S., Houwing, N., & van Iersel, T. (2005). First human exposure to sugammadex, a modified gamma-cyclodextrin for reversal of rocuronium-induced neuromuscular blockade. Anesthesiology, 103(4), 695-703.
4. Sacan, O., White, P. F., Tufanogullari, B., & Klein, K. (2007). Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and placebo. Anesthesia & Analgesia, 104(3), 569-574.
5. Nicholson, W. T., Sprung, J., & Jankowski, C. J. (2007). Sugammadex: a novel agent for the reversal of neuromuscular blockade. Pharmacotherapy, 27(10), 1400-1414.
6. Yang, L. P., & Keam, S. J. (2009). Sugammadex: a review of its use in anaesthetic practice. Drugs, 69(7), 919-947.
7. Ploeger, B. A., Smeets, J., Strougo, A., Drenth, H. J. H., Danhof, M., & DeJongh, J. (2009). Pharmacokinetic-pharmacodynamic model for the reversal of rocuronium-induced neuromuscular blockade by sugammadex. Anesthesiology, 110(1), 95-105.
8. Chambers, D., Paulden, M., Paton, F., Heirs, M., Duffy, S., Craig, D., … & Woolacott, N. (2010). Sugammadex for the reversal of muscle relaxation in general anaesthesia: a systematic review and economic assessment. Health Technology Assessment, 14(39), 1-211.
9. Welliver, M. (2006). Sugammadex: a selective relaxant binding agent. AANA Journal, 74(5), 357-363.
10. Tarver, A. L., & Teicher, D. G. (2010). Sugammadex: a new class of muscle relaxant reversal agent. International Anesthesiology Clinics, 48(4), 47-59.
6-Deoxy-6-N,N-dimethylamino-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

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