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5-Hydroxyindole-2-carboxylic Acid (Highly Pure)

Original price was: $3,195.00.Current price is: $1,595.00.

Catalog Number: B2016293 (5 g)
5-Hydroxyindole-2-carboxylic Acid (Highly Pure) is a high quality reagent used in the preparation of oxadiazole analogs as SH2 inhibitors of tyrosine kinase ZAP-70. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

5/5 - (2 votes)

5-Hydroxyindole-2-carboxylic Acid (Highly Pure)
Catalog number: B2016293
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 g
Molecular Weight or Concentration: 177.16 g/mol
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: 5-Hydroxyindole-2-carboxylic acid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Pierson PD, Fettes A, Freichel C, Gatti-McArthur S, Hertel C, Huwyler J, Mohr P, Nakagawa T, Nettekoven M, Plancher JM, Raab S, Richter H, Roche O, Rodríguez Sarmiento RM, Schmitt M, Schuler F, Takahashi T, Taylor S, Ullmer C, Wiegand R. 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity J Med Chem. 2009 Jul 9;52(13):3855-68.
2: Aroca P, Solano F, Garcia-Borrón JC, Lozano JA. Specificity of dopachrome tautomerase and inhibition by carboxylated indoles. Considerations on the enzyme active site Biochem J. 1991 Jul 15;277 ( Pt 2)(Pt 2):393-7.
3: Cuevas AA, García-Castiñeiras S. Melanins and lens pigments: a comparative study P R Health Sci J. 1993 Jun;12(2):129-35.
4: Ritschdorff ET, Plenert ML, Shear JB. Microsecond analysis of transient molecules using bi-directional capillary electrophoresis Anal Chem. 2009 Nov 1;81(21):8790-6.
5: Du F, Zhou Q, Sun W, Yang C, Wu C, Wang L, Chen G. 5-Hydroxyindole-Based EZH2 Inhibitors Assembled via TCCA-Catalyzed Condensation and Nenitzescu Reactions Molecules. 2020 Apr 28;25(9):2059.
6: Waclawiková B, Bullock A, Schwalbe M, Aranzamendi C, Nelemans SA, van Dijk G, El Aidy S. Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels PLoS Biol. 2021 Jan 22;19(1):e3001070.
7: Southgate J, Sandler M. 5-hydroxyindole metabolism in pregnancy Adv Pharmacol (1962). 1968;6(Pt B):179-86.
8: Moroni F, Carpenedo R, Mannaioni G, Galli A, Chiarugi A, Carlà V, Moneti G. Studies on the pharmacological properties of oxindole (2-hydroxyindole) and 5-hydroxyindole: are they involved in hepatic encephalopathy? Adv Exp Med Biol. 1997;420:57-73.
9: Fredj Z, Ali M, Singh B, Dempsey E. Simultaneous voltammetric detection of 5-hydroxyindole-3-acetic acid and 5-hydroxytryptamine using a glassy carbon electrode modified with conducting polymer and platinised carbon nanofibers Mikrochim Acta. 2018 Aug 13;185(9):412.
10: Murray-Lyon IM, Sandler M, Cheetham HD, Watts JA, Williams R. 5-Hydroxyindole-secreting rectal carcinoid tumour Gut. 1972 May;13(5):385-6.

Products Related to 5-Hydroxyindole-2-carboxylic Acid (Highly Pure) can be found at Chemicals

Additional Information

Weight 0.8 oz
Dimensions 2 × 0.9 × 0.9 in
5/5 - (2 votes)

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