5-Fluoroorotic Acid Monohydrate (5-FOA)

Product Description

5-Fluoroorotic Acid Monohydrate (5-FOA)
Catalog number: B2015500
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 g
Molecular Weight or Concentration: 192.10 g/mol
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: 5-Fluorouracil-4-carboxylic acid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Boeke JD, Trueheart J, Natsoulis G, Fink GR. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics Methods Enzymol. 1987;154:164-75.
2: Rathod PK, Khatri A, Hubbert T, Milhous WK. Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro Antimicrob Agents Chemother. 1989 Jul;33(7):1090-4.
3: Nakazawa T, Tsuzuki M, Irie T, Sakamoto M, Honda Y. Marker recycling via 5-fluoroorotic acid and 5-fluorocytosine counter-selection in the white-rot agaricomycete Pleurotus ostreatus Fungal Biol. 2016 Sep;120(9):1146-55.
4: Yano T, Sanders C, Catalano J, Daldal F. sacB-5-Fluoroorotic acid-pyrE-based bidirectional selection for integration of unmarked alleles into the chromosome of Rhodobacter capsulatus Appl Environ Microbiol. 2005 Jun;71(6):3014-24.
5: Cuellar A, Alcolea Palafox M, Rastogi VK, Kiefer W, Schlücker S, Rathor SK. FT-IR and FT-Raman spectra of 5-fluoroorotic acid with solid state simulation by DFT methods Spectrochim Acta A Mol Biomol Spectrosc. 2014 Nov 11;132:430-45.
6: Schneider AG, Schmalle HW, Arod F, Dubler E. The interaction of 5-fluoroorotic acid with transition metals: synthesis and characterisation of Ni(II), Cu(II) and Zn(II) complexes J Inorg Biochem. 2002 Apr 28;89(3-4):227-36.
7: Krooth RS, Hsiao WL, Potvin BW. Resistance to 5-fluoroorotic acid and pyrimidine auxotrophy: a new bidirectional selective system for mammalian cells Somatic Cell Genet. 1979 Sep;5(5):551-69.
8: WAGNER NJ, HEIDELBERGER C. Some effects of 5-fluoroorotic acid and 5-fluorouracii on the soluble acid of rat liver Biochim Biophys Acta. 1962 Sep 17;61:373-9.
9: Eriksson G, Stenram U. The effect of 5-fluoroorotic acid on the early labelling of nucleotides and RNA in whole liver and of RNA in subnuclear fractions in rats given 3H-orotic acid Adv Exp Med Biol. 1984;165 Pt A:543-5.
10: CHAUDHURI NK, MONTAG BJ, HEIDELBERGER C. Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo Cancer Res. 1958 Apr;18(3):318-28.

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