3-Cyano-7-ethoxycoumarin (Highly Pure)

Product Description

3-Cyano-7-ethoxycoumarin (Highly Pure)
Catalog number: B2012863
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 215.2 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: 7-ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: White IN. A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin Anal Biochem. 1988 Aug 1;172(2):304-10.
2: Ekins S, Vandenbranden M, Ring BJ, Gillespie JS, Yang TJ, Gelboin HV, Wrighton SA. Further characterization of the expression in liver and catalytic activity of CYP2B6 J Pharmacol Exp Ther. 1998 Sep;286(3):1253-9.
3: Fuchshuber-Moraes M, Carvalho RS, Rimmbach C, Rosskopf D, Carvalho MA, Suarez-Kurtz G. Aminoglycoside-induced suppression of CYP2C19*3 premature stop codon Pharmacogenet Genomics. 2011 Nov;21(11):694-700.
4: Stresser DM, Turner SD, Blanchard AP, Miller VP, Crespi CL. Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4 Drug Metab Dispos. 2002 Jul;30(7):845-52.
5: Dong AN, Ahemad N, Pan Y, Palanisamy UD, Yiap BC, Ong CE. Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B Drug Metab Bioanal Lett. 2022;15(1):51-63.
6: Smith EM, Wilson JY. Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16alpha-carbonitrile, rifampicin, and beta-naphthoflavone Aquat Toxicol. 2010 May 10;97(4):324-33.
7: Ghosal A, Hapangama N, Yuan Y, Lu X, Horne D, Patrick JE, Zbaida S. Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes Biopharm Drug Dispos. 2003 Dec;24(9):375-84.
8: Makaji E, Trambitas CS, Shen P, Holloway AC, Crankshaw DJ. Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms Toxicol Sci. 2010 Feb;113(2):293-304.
9: Pan Y, Tiong KH, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Ong CE. In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity Phytomedicine. 2014 Oct 15;21(12):1645-50.
10: Koenig S, Fernández P, Solé M. Differences in cytochrome P450 enzyme activities between fish and crustacea: relationship with the bioaccumulation patterns of polychlorobiphenyls (PCBs) Aquat Toxicol. 2012 Feb;108:11-7.

Products Related to 3-Cyano-7-ethoxycoumarin (Highly Pure) can be found at Substrates