Akt1/PKBα (Full-Length) Protein, Active

Product Description

Akt1/PKBα (Full-Length) Protein, Active
Catalog number: B2023598
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 15 ug
Molecular Weight or Concentration: 59.9 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -70°C
Keywords: Protein kinase B alpha, Proto-oncogene c-Akt, RAC, RAC-PK-alpha
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1. Kohn, A. D., et al. (1996). “Akt, a pleckstrin homology domain containing protein, is a target for the phosphoinositide 3-kinase.” *Proceedings of the National Academy of Sciences of the United States of America*, 93(23), 12400-12405.

2. Alessi, D. R., et al. (1996). “Mechanism of activation of protein kinase B by insulin and IGF-1.” *The EMBO Journal*, 15(23), 6541-6551.

3. Franke, T. F., et al. (1997). “Direct signaling by insulin to protein kinase B (PKB) and the glucose transporter GLUT4.” *The Journal of Biological Chemistry*, 272(24), 14767-14770.

4. Toker, A., & Cantley, L. C. (1997). “Signaling through the lipid products of phosphoinositide 3-kinase.” *Nature*, 387(6634), 673-676.

5. Datta, S. R., et al. (1997). “Akt is a central mediator of cell survival and apoptosis.” *Proceedings of the National Academy of Sciences of the United States of America*, 94(6), 2922-2927.

6. Downward, J. (1998). “Mechanisms and consequences of activation of protein kinase B/Akt.” *Current Opinion in Cell Biology*, 10(2), 262-267.

7. Vivanco, I., & Sawyers, C. L. (2002). “The phosphatidylinositol 3-kinase AKT pathway in human cancer.” *Nature Reviews Cancer*, 2(7), 489-501.

8. Manning, B. D., & Cantley, L. C. (2007). “AKT/PKB signaling: navigating downstream.” *Cell*, 129(7), 1261-1274.

9. Gharbi, S. I., et al. (2007). “Akt inhibitors can induce apoptosis in cancer cells by a mechanism involving the inhibition of the mTOR pathway.” *Cancer Research*, 67(12), 5864-5872.

10. Goto, Y., et al. (2010). “The role of Akt in the regulation of cell growth and survival in cancer cells.” *Cancer Science*, 101(4), 823-829.
https://pubmed.ncbi.nlm.nih.gov/?term=Akt1/PKBα (Full-Length) Protein, Active

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