2,3-Dimethoxy-5-methyl-1,4-benzoquinone (Highly Pure)


Catalog Number: B2012388 (25 mg)
2,3-Dimethoxy-5-methyl-1,4-benzoquinone (Highly Pure) is a high quality derivative of benzoquinone carrying a 5-methyl substituent. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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2,3-Dimethoxy-5-methyl-1,4-benzoquinone (Highly Pure)
Catalog number: B2012388
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 mg
Molecular Weight or Concentration: 182.18
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Coenzyme Q10
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Roginsky VA, Bruchelt G, Bartuli O. Ubiquinone-0 (2,3-dimethoxy-5-methyl-1,4-benzoquinone) as effective catalyzer of ascorbate and epinephrine oxidation and damager of neuroblastoma cells Biochem Pharmacol. 1998 Jan 1;55(1):85-91.
2: Amano T, Terao S, Imada I. Effects of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) and related benzoquinones on porcine pancreas phospholipase A2 activity Biol Pharm Bull. 1995 May;18(5):779-81.
3: Belliere J, Devun F, Cottet-Rousselle C, Batandier C, Leverve X, Fontaine E. Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death J Bioenerg Biomembr. 2012 Feb;44(1):207-12.
4: Hseu YC, Tseng YF, Pandey S, Shrestha S, Lin KY, Lin CW, Lee CC, Huang ST, Yang HL. Coenzyme Q(0) Inhibits NLRP3 Inflammasome Activation through Mitophagy Induction in LPS/ATP-Stimulated Macrophages Oxid Med Cell Longev. 2022 Jan 7;2022:4266214.
5: Sanchez-Cruz P, Garcia C, Alegria AE. Role of quinones in the ascorbate reduction rates of S-nitrosoglutathione Free Radic Biol Med. 2010 Nov 15;49(9):1387-94.
6: Sugihara H, Watanabe M, Kawamatsu Y, Morimoto H. [Ubiquinones and related compounds. XXII. Synthesis of 2,3-dimethoxy-5-methyl-1,4-benzoquinone and its ethylhomologues] Justus Liebigs Ann Chem. 1972 Sep;763:109-20.
7: Okamoto K, Watanabe M, Morimoto H, Imada I. Synthesis, metabolism, and in vitro biological activities of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (CV-2619)-related compounds Chem Pharm Bull (Tokyo). 1988 Jan;36(1):178-89.
8: Okamoto K, Imada I, Imamoto T. Effect of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (CV-2619) on microsomal lipid peroxidation Chem Pharm Bull (Tokyo). 1986 Jul;34(7):2821-7.
9: Sanchez-Cruz P, Santos A, Diaz S, Alegría AE. Metal-independent reduction of hydrogen peroxide by semiquinones Chem Res Toxicol. 2014 Aug 18;27(8):1380-6.
10: Kobayashi T, Yoshida K, Mitani M, Torii H, Tanayama S. Metabolism of idebenone (CV-2619), a new cerebral metabolism improving agent: isolation and identification of metabolites in the rat and dog J Pharmacobiodyn. 1985 Jun;8(6):448-56.

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