(2-Hydroxypropyl)-β-cyclodextrin (Highly Pure)


Catalog Number: B2010636 (1 g)
(2-Hydroxypropyl)-β-cyclodextrin (Highly Pure) is a highly pure chemically-modified cyclic oligosaccharide. This product has been used as a versatile molecular tool in solubility studies. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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(2-Hydroxypropyl)-β-cyclodextrin (Highly Pure)
Catalog number: B2010636
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 g
Molecular Weight or Concentration: 1396 Da
Supplied as: Powder
Applications: versatile molecular tools in solubility studies
Storage: RT
Keywords: HP-β-CD
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Lu H, Sun J, Liang W, Chang Z, Rom O, Zhao Y, Zhao G, Xiong W, Wang H, Zhu T,
Guo Y, Chang L, Garcia-Barrio MT, Zhang J, Chen YE, Fan Y. Cyclodextrin Prevents
Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell
Transcription Factor EB. Circulation. 2020 Aug 4;142(5):483-498. .

2: Stappaerts J, Berben P, Cevik I, Augustijns P. The effect of 2-hydroxypropyl-
β-cyclodextrin on the intestinal permeation through mucus. Eur J Pharm Sci. 2018
Mar 1;114:238-244.

3: Conceição J, Adeoye O, Cabral-Marques HM, Sousa Lobo JM. Hydroxypropyl-β-
Cyclodextrin and β-Cyclodextrin as Tablet Fillers for Direct Compression. AAPS
PharmSciTech. 2018 Aug;19(6):2710-2718.

4: Cheng Q, Liu G, Zhang P, Xu W, Tang K. Lipase-catalyzed hydrolysis of
(R,S)-2,3-diphenylpropionic methyl ester enhanced by hydroxypropyl-β-
cyclodextrin. Biotechnol Prog. 2018 Nov;34(6):1355-1362. d

5: Pons-Faudoa FP, Sizovs A, Di Trani N, Paez-Mayorga J, Bruno G, Rhudy J,
Manohar M, Gwenden K, Martini C, Chua CYX, Varchi G, Marzinke MA, Grattoni A.
2-Hydroxypropyl-β-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a
nanofluidic implant for HIV pre-exposure prophylaxis. J Control Release. 2019
Jul 28;306:89-96.

6: Ding Y, Pang Y, Vara Prasad CVNS, Wang B. Formation of inclusion complex of
enrofloxacin with 2-hydroxypropyl-β-cyclodextrin. Drug Deliv. 2020

7: Gaspar J, Mathieu J, Alvarez P. 2-Hydroxypropyl-beta-cyclodextrin (HPβCD)
reduces age-related lipofuscin accumulation through a cholesterol-associated
pathway. Sci Rep. 2017 May 19;7(1):2197.

8: Sun H, Zong H, Wu G. 2‑Hydroxypropyl‑β‑cyclodextrin blocks autophagy flux and
triggers caspase‑8‑mediated apoptotic cascades in HepG2 cells. Mol Med Rep. 2020

9: Leonis G, Christodoulou E, Ntountaniotis D, Chatziathanasiadou MV,
Mavromoustakos T, Naziris N, Chountoulesi M, Demetzos C, Valsami G, Damalas DE,
Tzakos AG, Thomaidis NS, Karageorgos V, Liapakis G. Antihypertensive activity
and molecular interactions of irbesartan in complex with 2-hydroxypropyl-β-
cyclodextrin. Chem Biol Drug Des. 2020 Jul;96(1):668-683.
0: El-Darzi N, Mast N, Petrov AM, Pikuleva IA. 2-Hydroxypropyl-β-cyclodextrin
reduces retinal cholesterol in wild-type and Cyp27a1-/-
Cyp46a1-/- mice with deficiency in the oxysterol production. Br J
Pharmacol. 2021 Aug;178(16):3220-3234.

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