11β-HSD1 CRISPR Plasmids

Product Description

11β-HSD1 CRISPR Plasmids
Catalog number: B2015183
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: 2 – 8 °C
Keywords: 11β-HSD1 CRISPR Plasmids
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Akalestou E, Lopez-Noriega L, Christakis I, Hu M, Miras AD, Leclerc I, Rutter GA. Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice Front Endocrinol (Lausanne). 2022 Sep 29;13:1020576.
2: Kragl A, Schoon J, Tzvetkova A, Wenzel C, Blaschke M, Böcker W, Siggelkow H, Tzvetkov MV. Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells Front Bioeng Biotechnol. 2022 Aug 25;10:953034.
3: Brooks K, Burns G, Spencer TE. Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation Biol Reprod. 2015 Aug;93(2):38.
4: Taves MD, Otsuka S, Taylor MA, Donahue KM, Meyer TJ, Cam MC, Ashwell JD. Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth J Clin Invest. 2023 Sep 15;133(18):e164599.
5: Chuanxin Z, Shengzheng W, Lei D, Duoli X, Jin L, Fuzeng R, Aiping L, Ge Z. Progress in 11β-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development Eur J Med Chem. 2020 Apr 1;191:112134.
6: Gray GA, White CI, Castellan RF, McSweeney SJ, Chapman KE. Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium J Mol Endocrinol. 2017 Jan;58(1):R1-R13.
7: Leiva R, McBride A, Binnie M, Webster SP, Vázquez S. Exploring N-acyl-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-enes as 11β-HSD1 Inhibitors Molecules. 2018 Feb 28;23(3):536.
8: Morgan SA, Gathercole LL, Hassan-Smith ZK, Tomlinson J, Stewart PM, Lavery GG. 11β-HSD1 contributes to age-related metabolic decline in male mice J Endocrinol. 2022 Oct 7;255(3):117-129.
9: Chapman KE, Seckl JR. 11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function Neurochem Res. 2008 Apr;33(4):624-36.
10: Wang W, Chen ZJ, Myatt L, Sun K. 11β-HSD1 in Human Fetal Membranes as a Potential Therapeutic Target for Preterm Birth Endocr Rev. 2018 Jun 1;39(3):241-260.

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