11β-HSD1 CRISPR/Cas9 KO Plasmid

Product Description

11β-HSD1 CRISPR/Cas9 KO Plasmid
Catalog number: B2015147
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: 2-8 °C
Keywords: 11β-HSD1 CRISPR/Cas9 KO Plasmid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Akalestou E, Lopez-Noriega L, Christakis I, Hu M, Miras AD, Leclerc I, Rutter GA. Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice Front Endocrinol (Lausanne). 2022 Sep 29;13:1020576.
2: Kragl A, Schoon J, Tzvetkova A, Wenzel C, Blaschke M, Böcker W, Siggelkow H, Tzvetkov MV. Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells Front Bioeng Biotechnol. 2022 Aug 25;10:953034.
3: Brooks K, Burns G, Spencer TE. Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation Biol Reprod. 2015 Aug;93(2):38.
4: Zhang Z, Coutinho AE, Man TY, Kipari TMJ, Hadoke PWF, Salter DM, Seckl JR, Chapman KE. Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis J Endocrinol. 2017 Sep;234(3):291-299.
5: Morgan SA, Tomlinson JW. 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes Expert Opin Investig Drugs. 2010 Sep;19(9):1067-76.
6: Masuzaki H, Flier JS. Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)–a promising drug target for the treatment of metabolic syndrome Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62.
7: Stimson RH, Walker BR. Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome Minerva Endocrinol. 2007 Sep;32(3):141-59.
8: Hughes KA, Webster SP, Walker BR. 11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity Expert Opin Investig Drugs. 2008 Apr;17(4):481-96.
9: Mylonas KJ, Turner NA, Bageghni SA, Kenyon CJ, White CI, McGregor K, Kimmitt RA, Sulston R, Kelly V, Walker BR, Porter KE, Chapman KE, Gray GA. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI J Endocrinol. 2017 Jun;233(3):315-327.
10: Duan X, Xin H, Yan H. Design, synthesis, and biological evaluation of 1,4-diaryl-1,4-dihydropyrazines as novel 11β-HSD1 inhibitors Biol Pharm Bull. 2014;37(5):840-6.

Products Related to 11β-HSD1 CRISPR/Cas9 KO Plasmid can be found at DNA