1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate, C18 LPA
Original price was: $1,595.00.$795.00Current price is: $795.00.
Catalog Number: B2019026 (1 mg)
1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate, or C18 LPA, is a lysophospholipid with a glycerol backbone, an 18-carbon fatty acid, and a phosphate group. It plays a role in cell signaling and can activate LPA receptors involved in various physiological processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.
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In stock
Product Description
1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate, C18 LPA
Catalog number: B2019026
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 441 g/mol
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: −20°C
Keywords: C18 LPA, 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), 1-octadecyl-sn-glycero-3-phosphate (ammonium salt), PA(18:0e/0:0)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Maher TM, van der Aar EM, Van de Steen O, Allamassey L, Desrivot J, Dupont S, Fagard L, Ford P, Fieuw A, Wuyts W. Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial Lancet Respir Med. 2018 Aug;6(8):627-635.
2: Zhou Y, Huang X, Hao Y, Cai G, Shi X, Li R, Wang J. [Cloning and functional characterization of a lysophosphatidic acid acyltransferase gene from Perilla frutescens] Sheng Wu Gong Cheng Xue Bao. 2022 Aug 25;38(8):3014-3028.
3: Cho HJ, Choi SH, Kim HJ, Lee BH, Rhim H, Kim HC, Hwang SH, Nah SY. Bioactive lipids in gintonin-enriched fraction from ginseng J Ginseng Res. 2019 Apr;43(2):209-217.
4: Khanna D, Denton CP, Furst DE, Mayes MD, Matucci-Cerinic M, Smith V, de Vries D, Ford P, Bauer Y, Randall MJ, Ebrahimpoor M, Kupcsik L, Stiers PJ, Deberdt L, Prasad N, Lim S, Pujuguet P, Ahmed S. A 24-Week, Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis Arthritis Rheumatol. 2023 Aug;75(8):1434-1444.
5: Kim HJ, Silva JE, Iskandarov U, Andersson M, Cahoon RE, Mockaitis K, Cahoon EB. Structurally divergent lysophosphatidic acid acyltransferases with high selectivity for saturated medium chain fatty acids from Cuphea seeds Plant J. 2015 Dec;84(5):1021-33.
6: Chagas-Lima AC, Pereira MG, Fampa P, Lima MS, Kluck GEG, Atella GC. Bioactive lipids regulate Trypanosoma cruzi development Parasitol Res. 2019 Sep;118(9):2609-2619.
7: Kim SH, Song JH, Kim J, Kang DK. Characterisation of a lysophospholipase from Lactobacillus mucosae Biotechnol Lett. 2020 Sep;42(9):1735-1741.
8: Adachi M, Horiuchi G, Ikematsu N, Tanaka T, Terao J, Satouchi K, Tokumura A. Intragastrically administered lysophosphatidic acids protect against gastric ulcer in rats under water-immersion restraint stress Dig Dis Sci. 2011 Aug;56(8):2252-61.
9: Taneja A, Jentsch G, Delage S, Randall MJ, van den Blink B, Bauer Y, Namour F. ISABELA Studies: Plasma Exposure and Target Engagement Do Not Explain the Lack of Efficacy of Ziritaxestat in Patients with Idiopathic Pulmonary Fibrosis Clin Pharmacol Ther. 2024 Mar;115(3):606-615.
10: Sattikar A, Dowling MR, Rosethorne EM. Endogenous lysophosphatidic acid (LPA(1) ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts Br J Pharmacol. 2017 Feb;174(3):227-237.
Products Related to 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate, C18 LPA can be found at Lipids
Additional Information
| Weight | 0.15 oz |
|---|---|
| Dimensions | 2 × 0.5 × 0.5 in |
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