1-Methyl-D-tryptophan

Product Description

1-Methyl-D-tryptophan
Catalog number: B2016131
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 mg
Molecular Weight or Concentration: 218.25
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: RT, Dry
Keywords: (2R)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, D-(+)-1-Methyltryptophan
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Matheus LHG, Dalmazzo SV, Brito RBO, Pereira LA, de Almeida RJ, Camacho CP, Dellê H. 1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression BMC Cancer. 2020 Sep 9;20(1):869.
2: Alahdal M, Xing Y, Tang T, Liang J. 1-Methyl-D-tryptophan Reduces Tumor CD133(+) cells, Wnt/β-catenin and NF-κβp65 while Enhances Lymphocytes NF-κβ2, STAT3, and STAT4 Pathways in Murine Pancreatic Adenocarcinoma Sci Rep. 2018 Jun 29;8(1):9869.
3: Jia L, Schweikart K, Tomaszewski J, Page JG, Noker PE, Buhrow SA, Reid JM, Ames MM, Munn DH. Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption Food Chem Toxicol. 2008 Jan;46(1):203-11.
4: Brito RB, Malta CS, Souza DM, Matheus LH, Matos YS, Silva CS, Ferreira JM, Nunes VS, França CM, Dellê H. 1-Methyl-D-tryptophan potentiates TGF-β-induced epithelial-mesenchymal transition in T24 human bladder cancer cells PLoS One. 2015 Aug 12;10(8):e0134858.
5: Liu Y, Xie J, Zhao X, Zhang Y, Zhong Z, Deng C. A polymeric IDO inhibitor based on poly(ethylene glycol)-b-poly(L-tyrosine-co-1-methyl-D_tryptophan) enables facile trident cancer immunotherapy Biomater Sci. 2022 Sep 27;10(19):5731-5743.
6: Opitz CA, Litzenburger UM, Opitz U, Sahm F, Ochs K, Lutz C, Wick W, Platten M. The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D_tryptophan upregulates IDO1 in human cancer cells PLoS One. 2011;6(5):e19823.
7: Huang GL, Tao A, Miyazaki T, Khan T, Hong T, Nakagawa Y, Cabral H. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase Nanomaterials (Basel). 2019 May 9;9(5):719.
8: Cho T, Kok LY, Uetrecht J. Testing Possible Risk Factors for Idiosyncratic Drug-Induced Liver Injury Using an Amodiaquine Mouse Model and Co-treatment with 1-Methyl-d_Tryptophan or Acetaminophen ACS Omega. 2021 Feb 7;6(7):4656-4662.
9: Metz R, Rust S, Duhadaway JB, Mautino MR, Munn DH, Vahanian NN, Link CJ, Prendergast GC. IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan Oncoimmunology. 2012 Dec 1;1(9):1460-1468.
10: Laugeray A, Launay JM, Callebert J, Mutlu O, Guillemin GJ, Belzung C, Barone PR. Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice – Comparison with Fluoxetine PLoS One. 2016 Nov 9;11(11):e0164337.

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