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A new interesting article has been published in Data Brief. 2019 Nov 8; 27:104781. doi: 10.1016/j.dib.2019.104781. eCollection 2019 Dec. and titled:

Data on hydroxychloroquine interference with urine laboratory testing.

Authors of this article are:

Kingery JM, Radke JB, Maakestad J, Krasowski MD.

A summary of the article is shown below:

Hydroxychloroquine is a medication used to treat rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune disorders. Previous studies have shown that hydroxychloroquine and the structurally related drug chloroquine have the potential to interfere with some common urine chemistry tests, especially at high concentrations. In the related research article, we observed suspected interference with urine drug of abuse testing in a patient who ingested approximately 12 g of hydroxychloroquine in an acute overdose, with urine hydroxychloroquine concentrations exceeding 500 mg/L. This case prompted a more detailed investigation of the effects of hydroxychloroquine spiked into pooled de-identified urine specimens from a hospital clinical laboratory. The data in this article provides the raw data for 24 urine assays that were investigated. The analyzed data is provided in the tables included in this article. The dataset reported is related to the research article entitled “Diagnostic Pitfalls and Laboratory Test Interference After Hydroxychloroquine Intoxication: A Case Report” [1].© 2019 The Author(s).

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31799344 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Absorbance error; Assay interference; Clinical chemistry tests; Drug of abuse testing; Hydroxychloroquine; Photometry.

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