Uroguanylin Isomer A (Human)

Product Description

Uroguanylin Isomer A (Human)
Catalog number: MDP0667
CAS Number: 252642-12-9
Sequence: Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu (Disulfide bonds between Cys4-Cys12 and Cys7-Cys15)
Amount: 100 ug
Molecular Weight: 1667.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Moss NG, Riguera DA, Solinga RM, Kessler MM, Zimmer DP, Arendshorst WJ, Currie MG, Goy MF. The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers Hypertension. 2009 May;53(5):867-76.
2: Marx UC, Klodt J, Meyer M, Gerlach H, Rösch P, Forssmann WG, Adermann K. One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers J Pept Res. 1998 Sep;52(3):229-40.
3: Kinoshita H, Fujimoto S, Nakazato M, Yokota N, Date Y, Yamaguchi H, Hisanaga S, Eto T. Urine and plasma levels of uroguanylin and its molecular forms in renal diseases Kidney Int. 1997 Oct;52(4):1028-34.
4: Lauber T, Marx UC. Prosequence-mediated disulfide coupled folding of the peptide hormones guanylin and uroguanylin Protein Pept Lett. 2005 Feb;12(2):153-8.
5: Nakazato M, Yamaguchi H, Date Y, Miyazato M, Kangawa K, Goy MF, Chino N, Matsukura S. Tissue distribution, cellular source, and structural analysis of rat immunoreactive uroguanylin Endocrinology. 1998 Dec;139(12):5247-54.
6: Hidaka Y, Ohno M, Hemmasi B, Hill O, Forssmann WG, Shimonishi Y. In vitro disulfide-coupled folding of guanylyl cyclase-activating peptide and its precursor protein Biochemistry. 1998 Jun 9;37(23):8498-507.
7: Klodt J, Kuhn M, Marx UC, Martin S, Rösch P, Forssmann WG, Adermann K. Synthesis, biological activity and isomerism of guanylate cyclase C-activating peptides guanylin and uroguanylin J Pept Res. 1997 Sep;50(3):222-30.
8: Schulz A, Escher S, Marx UC, Meyer M, Rösch P, Forssmann WG, Adermann K. Carboxy-terminal extension stabilizes the topological stereoisomers of guanylin J Pept Res. 1998 Dec;52(6):518-25.
9: Chino N, Kubo S, Kitani T, Yoshida T, Tanabe R, Kobayashi Y, Nakazato M, Kangawa K, Kimura T. Topological isomers of human uroguanylin: interconversion between biologically active and inactive isomers FEBS Lett. 1998 Jan 2;421(1):27-31.
10: Schulz A, Marx UC, Tidten N, Lauber T, Hidaka Y, Adermann K. Side chain contributions to the interconversion of the topological isomers of guanylin-like peptides J Pept Sci. 2005 Jun;11(6):319-30.

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