TMRM (Highly Pure)


Catalog Number: B2011225 (5 mg)
TMRM (Highly Pure) is a high quality cationic fluorescent dye used in the measurement of membrane potential in mitochondria. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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TMRM (Highly Pure)
Catalog number: B2011225
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 501 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Tetramethylrhodamine methyl ester perchlorate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Creed S, McKenzie M. Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester (TMRM) Methods Mol Biol. 2019;1928:69-76.
2: Chazotte B. Labeling mitochondria with MitoTracker dyes Cold Spring Harb Protoc. 2011 Aug 1;2011(8):990-2.
3: Wallberg F, Tenev T, Meier P. Analysis of Apoptosis and Necroptosis by Fluorescence-Activated Cell Sorting Cold Spring Harb Protoc. 2016 Apr 1;2016(4):pdb.prot087387.
4: Fernandez-Mosquera L, Yambire KF, Couto R, Pereyra L, Pabis K, Ponsford AH, Diogo CV, Stagi M, Milosevic I, Raimundo N. Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis Autophagy. 2019 Sep;15(9):1572-1591.
5: Vasilev A, Sofi R, Smith SJ, Rahman R, Teschemacher AG, Kasparov S. Feasibility of Photodynamic Therapy for Glioblastoma with the Mitochondria-Targeted Photosensitizer Tetramethylrhodamine Methyl Ester (TMRM) Biomedicines. 2021 Oct 13;9(10):1453.
6: Mei H, Zhao L, Li W, Zheng Z, Tang D, Lu X, He Y. Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity J Cell Mol Med. 2020 Oct;24(20):12065-12081.
7: Rabinovich-Nikitin I, Rasouli M, Reitz CJ, Posen I, Margulets V, Dhingra R, Khatua TN, Thliveris JA, Martino TA, Kirshenbaum LA. Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress Autophagy. 2021 Nov;17(11):3794-3812.
8: Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, Kim T, Sussman MA, Gustafsson ÅB. BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation Autophagy. 2019 Jul;15(7):1182-1198.
9: Uribe P, Villegas JV, Boguen R, Treulen F, Sánchez R, Mallmann P, Isachenko V, Rahimi G, Isachenko E. Use of the fluorescent dye tetramethylrhodamine methyl ester perchlorate for mitochondrial membrane potential assessment in human spermatozoa Andrologia. 2017 Nov;49(9).
10: Yazdankhah M, Ghosh S, Shang P, Stepicheva N, Hose S, Liu H, Chamling X, Tian S, Sullivan MLG, Calderon MJ, Fitting CS, Weiss J, Jayagopal A, Handa JT, Sahel JA, Zigler JS Jr, Kinchington PR, Zack DJ, Sinha D. BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes Autophagy. 2021 Oct;17(10):3140-3159.

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